1º de Agosto 2-2 Future FC *
| 09.11.2022 | Future FC | 1-1/p.3-2 | 1º de Agosto | |
| 02.11.2022 | 1º de Agosto | 1-1 | Future FC | |
Al Ahli Tripoli 1-3 Marumo Gallants FC *
| 09.11.2022 | Marumo Gallants FC | 3-0 | Al Ahli Tripoli | |
| 02.11.2022 | Al Ahli Tripoli | 1-0 | Marumo Gallants FC | |
Plateau United 4-4 Al Akhdar SC *
| 09.11.2022 | Al Akhdar SC | 3-0 | Plateau United | |
| 02.11.2022 | Plateau United | 4-1 | Al Akhdar SC | |
Royal Leopards 2-4 AS Real Bamako *
| 09.11.2022 | AS Real Bamako | 3-1 | Royal Leopards | |
| 02.11.2022 | Royal Leopards | 1-1 | AS Real Bamako | |
*ASKO Kara 2-1 CS Sfaxien
| 09.11.2022 | CS Sfaxien | 0-0 | ASKO Kara | |
| 02.11.2022 | ASKO Kara | 2-1 | CS Sfaxien | |
Cape Town City 0-1 USM Alger *
| 09.11.2022 | USM Alger | 1-0 | Cape Town City | |
| 02.11.2022 | Cape Town City | 0-0 | USM Alger | |
Flambeau du Centre 1-4 DC Motema Pembe *
| 09.11.2022 | DC Motema Pembe | 2-1 | Flambeau du Centre | |
| 02.11.2022 | Flambeau du Centre | 0-2 | DC Motema Pembe | |
Djoliba AC 0-4 FAR Rabat *
| 09.11.2022 | FAR Rabat | 4-0 | Djoliba AC | |
| 02.11.2022 | Djoliba AC | 0-0 | FAR Rabat | |
La Passe FC 2-6 Diables Noirs *
| 09.11.2022 | Diables Noirs | 4-2 | La Passe FC | |
| 04.11.2022 | La Passe FC | 0-2 | Diables Noirs | |
*Rivers United 6-1 Nasr Benghazi
| 09.11.2022 | Nasr Benghazi | 1-1 | Rivers United | |
| 02.11.2022 | Rivers United | 5-0 | Nasr Benghazi | |
AS NIGELEC 1-3 Pyramids FC *
| 09.11.2022 | Pyramids FC | 3-0 | AS NIGELEC | |
| 02.11.2022 | AS NIGELEC | 1-0 | Pyramids FC | |
Rail Club Kadiogo 0-2 Saint Eloi Lupopo *
| 09.11.2022 | Saint Eloi Lupopo | 1-0 | Rail Club Kadiogo | |
| 02.11.2022 | Rail Club Kadiogo | 0-1 | Saint Eloi Lupopo | |
*US Monastir 1-0 Renaissance Berkane
| 09.11.2022 | Renaissance Berkane | 0-0 | US Monastir | |
| 02.11.2022 | US Monastir | 1-0 | Renaissance Berkane | |
*TP Mazembe 3-0 Royal AM
| 09.11.2022 | Royal AM | 0-1 | TP Mazembe | |
| 02.11.2022 | TP Mazembe | 2-0 | Royal AM | |
*ASEC Mimosas 5-2 SC Gagnoa
| 09.11.2022 | SC Gagnoa | 2-3 | ASEC Mimosas | |
| 02.11.2022 | ASEC Mimosas | 2-0 | SC Gagnoa | |
*Young Africans 1-0 Club Africain Tunis
| 09.11.2022 | Club Africain Tunis | 0-1 | Young Africans | |
| 02.11.2022 | Young Africans | 0-0 | Club Africain Tunis | |