*Al Akhdar SC 3-0 Ahli Khartoum
| 16.09.2022 | Ahli Khartoum | 0-0 | Al Akhdar SC | |
| 11.09.2022 | Al Akhdar SC | 3-0 | Ahli Khartoum | |
AS Douanes (BFA) 0-0 AS Real Bamako *
| 20.09.2022 | AS Real Bamako | 0-0/p.3-1 | AS Douanes (BFA) | |
| 13.09.2022 | AS Douanes (BFA) | 0-0 | AS Real Bamako | |
AS Sante d'Abeche 1-3 Ferroviário da Beira *
| 18.09.2022 | Ferroviário da Beira | 1-0 | AS Sante d'Abeche | |
| 10.09.2022 | AS Sante d'Abeche | 1-2 | Ferroviário da Beira | |
ASAS Djibouti Télécom 0-1 AS Kigali *
| 18.09.2022 | AS Kigali | 1-0 | ASAS Djibouti Télécom | |
| 10.09.2022 | ASAS Djibouti Télécom | 0-0 | AS Kigali | |
*Ashanti Golden Boys 2-1 Nouakchott King's
| 16.09.2022 | Nouakchott King's | 1-0 | Ashanti Golden Boys | |
| 10.09.2022 | Ashanti Golden Boys | 2-0 | Nouakchott King's | |
PWD Bamenda 1-2 ASSM Elgeco Plus *
| 18.09.2022 | ASSM Elgeco Plus | 1-0 | PWD Bamenda | |
| 10.09.2022 | PWD Bamenda | 1-1 | ASSM Elgeco Plus | |
*FAR Rabat 2-1 Remo Stars
| 18.09.2022 | Remo Stars | 0-1 | FAR Rabat | |
| 11.09.2022 | FAR Rabat | 1-1 | Remo Stars | |
*Fasil Kenema 3-1 Bumamuru FC
| 16.09.2022 | Bumamuru FC | 1-0 | Fasil Kenema | |
| 09.09.2022 | Fasil Kenema | 3-0 | Bumamuru FC | |
Buffles du Borgou 0-4 FC Kallon *
| 17.09.2022 | FC Kallon | 3-0 | Buffles du Borgou | |
| 09.09.2022 | Buffles du Borgou | 0-1 | FC Kallon | |
*Hilal Al Sahel 2-2 Geita Gold FC
| 17.09.2022 | Geita Gold FC | 2-1 | Hilal Al Sahel | |
| 11.09.2022 | Hilal Al Sahel | 1-0 | Geita Gold FC | |
Hilal Wau 2-2 Kipanga FC *
| 17.09.2022 | Kipanga FC | 1-1/p.4-3 | Hilal Wau | |
| 11.09.2022 | Hilal Wau | 1-1 | Kipanga FC | |
*St Michel United 6-0 Inter Litoral Academy
| 16.09.2022 | Inter Litoral Academy | 0-3 W.O. | St Michel United | |
| 09.09.2022 | St Michel United | 3-0 W.O. | Inter Litoral Academy | |
*Kwara United 3-0 AS Douanes Niamey
| 18.09.2022 | AS Douanes Niamey | 0-0 | Kwara United | |
| 11.09.2022 | Kwara United | 3-0 | AS Douanes Niamey | |
LISCR Monrovia 1-3 SC Gagnoa *
| 17.09.2022 | SC Gagnoa | 3-1 | LISCR Monrovia | |
| 11.09.2022 | LISCR Monrovia | 0-0 | SC Gagnoa | |
Mbabane Highlanders 0-2 Royal AM *
| 16.09.2022 | Royal AM | 2-0 | Mbabane Highlanders | |
| 11.09.2022 | Mbabane Highlanders | 0-0 | Royal AM | |
Security Systems 0-6 Saint Eloi Lupopo *
| 16.09.2022 | Saint Eloi Lupopo | 3-0 W.O. | Security Systems | |
| 09.09.2022 | Security Systems | 0-3 W.O. | Saint Eloi Lupopo | |