*AS Real Bamako 3-1 Accra Hearts of Oak
| 16.10.2022 | Accra Hearts of Oak | 1-0 | AS Real Bamako | |
| 08.10.2022 | AS Real Bamako | 3-0 | Accra Hearts of Oak | |
ASSM Elgeco Plus 1-4 Marumo Gallants FC *
| 15.10.2022 | Marumo Gallants FC | 1-0 | ASSM Elgeco Plus | |
| 09.10.2022 | ASSM Elgeco Plus | 1-3 | Marumo Gallants FC | |
*Al Akhdar SC 3-2 Azam FC
| 16.10.2022 | Azam FC | 2-0 | Al Akhdar SC | |
| 08.10.2022 | Al Akhdar SC | 3-0 | Azam FC | |
Kipanga FC 0-7 Club Africain Tunis *
| 16.10.2022 | Club Africain Tunis | 7-0 | Kipanga FC | |
| 08.10.2022 | Kipanga FC | 0-0 | Club Africain Tunis | |
St Michel United 1-2 DC Motema Pembe *
| 16.10.2022 | DC Motema Pembe | 2-0 | St Michel United | |
| 08.10.2022 | St Michel United | 1-0 | DC Motema Pembe | |
*FAR Rabat 5-0 Ashanti Golden Boys
| 14.10.2022 | Ashanti Golden Boys | 0-1 | FAR Rabat | |
| 09.10.2022 | FAR Rabat | 4-0 | Ashanti Golden Boys | |
Fasil Kenema 0-1 CS Sfaxien *
| 15.10.2022 | CS Sfaxien | 1-0 | Fasil Kenema | |
| 09.10.2022 | Fasil Kenema | 0-0 | CS Sfaxien | |
Ferroviário da Beira 2-4 Diables Noirs *
| 16.10.2022 | Diables Noirs | 3-0 | Ferroviário da Beira | |
| 08.10.2022 | Ferroviário da Beira | 2-1 | Diables Noirs | |
Hilal Al Sahel 0-9 Pyramids FC *
| 15.10.2022 | Pyramids FC | 7-0 | Hilal Al Sahel | |
| 08.10.2022 | Hilal Al Sahel | 0-2 | Pyramids FC | |
Kwara United 3-3 Renaissance Berkane *
| 15.10.2022 | Renaissance Berkane | 2-0 | Kwara United | |
| 09.10.2022 | Kwara United | 3-1 | Renaissance Berkane | |
AS Kigali 0-1 Nasr Benghazi *
| 16.10.2022 | Nasr Benghazi | 1-0 | AS Kigali | |
| 08.10.2022 | AS Kigali | 0-0 | Nasr Benghazi | |
*Saint Eloi Lupopo 2-0 Sagrada Esperanca
| 15.10.2022 | Sagrada Esperanca | 0-0 | Saint Eloi Lupopo | |
| 08.10.2022 | Saint Eloi Lupopo | 2-0 | Sagrada Esperanca | |
*Royal AM 1-1 ZESCO United
| 15.10.2022 | ZESCO United | 1-1 | Royal AM | |
| 09.10.2022 | Royal AM | 0-0 | ZESCO United | |