CD Marathón 0-4 CD Motagua *
| 03.11.2021 | CD Motagua | 2-0 | CD Marathón | |
| 22.10.2021 | CD Marathón | 0-2 | CD Motagua | |
Saprissa 5-5 CSD Comunicaciones *
| 04.11.2021 | CSD Comunicaciones | 2-1 | Saprissa | |
| 22.10.2021 | Saprissa | 4-3 | CSD Comunicaciones | |
Santos Guápiles 3-4 Forge FC *
| 03.11.2021 | Forge FC | 3-0 | Santos Guápiles | |
| 21.10.2021 | Santos Guápiles | 3-1 | Forge FC | |