Atlético Vega Real 0-9 CSD Municipal *
| 05.08.2022 | CSD Municipal | 5-0 | Atlético Vega Real | |
| 29.07.2022 | Atlético Vega Real | 0-4 | CSD Municipal | |
Deportivo Malacateco 1-4 Sporting San Miguelito *
| 04.08.2022 | Sporting San Miguelito | 3-0 | Deportivo Malacateco | |
| 28.07.2022 | Deportivo Malacateco | 1-1 | Sporting San Miguelito | |
CD Águila 1-4 LD Alajuelense *
| 03.08.2022 | LD Alajuelense | 3-0 | CD Águila | |
| 27.07.2022 | CD Águila | 1-1 | LD Alajuelense | |
Real Estelí 1-3 Real España *
| 05.08.2022 | Real España | 3-1 | Real Estelí | |
| 29.07.2022 | Real Estelí | 0-0 | Real España | |
*Verdes FC 2-2 Platense (SLV)
| 04.08.2022 | Platense (SLV) | 2-2 | Verdes FC | |
| 28.07.2022 | Verdes FC | 0-0 | Platense (SLV) | |
Waterhouse FC 0-6 Pacific FC *
| 03.08.2022 | Pacific FC | 6-0 | Waterhouse FC | |
| 27.07.2022 | Waterhouse FC | 0-0 | Pacific FC | |