Verdes FC 1-7 Alianza FC (SLV) *
| 25.08.2022 | Alianza FC (SLV) | 5-1 | Verdes FC | |
| 18.08.2022 | Verdes FC | 0-2 | Alianza FC (SLV) | |
CSD Municipal 2-3 CD Olimpia *
| 26.08.2022 | CD Olimpia | 1-0 | CSD Municipal | |
| 19.08.2022 | CSD Municipal | 2-2 | CD Olimpia | |
Cibao FC 0-3 CD Motagua *
| 25.08.2022 | CD Motagua | 2-0 | Cibao FC | |
| 18.08.2022 | Cibao FC | 0-1 | CD Motagua | |
*Real España 4-0 CS Cartaginés
| 26.08.2022 | CS Cartaginés | 0-2 | Real España | |
| 19.08.2022 | Real España | 2-0 | CS Cartaginés | |
CSD Comunicaciones 1-2 Diriangén FC *
| 24.08.2022 | Diriangén FC | 1-1 | CSD Comunicaciones | |
| 17.08.2022 | CSD Comunicaciones | 0-1 | Diriangén FC | |
*LD Alajuelense 6-1 Alianza FC (PAN)
| 26.08.2022 | Alianza FC (PAN) | 1-1 | LD Alajuelense | |
| 19.08.2022 | LD Alajuelense | 5-0 | Alianza FC (PAN) | |
Pacific FC 1-1 CS Herediano *
| 24.08.2022 | CS Herediano | 0-1/p.6-5 | Pacific FC | |
| 17.08.2022 | Pacific FC | 0-1 | CS Herediano | |
Sporting San Miguelito 1-2 Tauro FC *
| 24.08.2022 | Tauro FC | 1-1 | Sporting San Miguelito | |
| 17.08.2022 | Sporting San Miguelito | 0-1 | Tauro FC | |