Portmore United 3-7 Club América
| 09.03.2006 | Club América | 5-2 | Portmore United | |
| 23.02.2006 | Portmore United | 1-2 | Club América | |
CD Olimpia 1-4 Deportivo Toluca
| 08.03.2006 | Deportivo Toluca | 2-1 | CD Olimpia | |
| 23.02.2006 | CD Olimpia | 0-2 | Deportivo Toluca | |
New England Revs 0-1 LD Alajuelense
| 09.03.2006 | LD Alajuelense | 1-0 | New England Revs | |
| 23.02.2006 | New England Revs | 0-0 | LD Alajuelense | |
Los Angeles Galaxy 2-3 Saprissa
| 09.03.2006 | Saprissa | 3-2 AET | Los Angeles Galaxy | |
| 23.02.2006 | Los Angeles Galaxy | 0-0 | Saprissa | |