Antigua GFC 2-6 Seattle Sounders *
| 27.02.2025 | Seattle Sounders | 3-1 | Antigua GFC | |
| 20.02.2025 | Antigua GFC | 1-3 | Seattle Sounders | |
Cavalry FC 2-3 UNAM Pumas *
| 14.02.2025 | UNAM Pumas | 2-0 | Cavalry FC | |
| 07.02.2025 | Cavalry FC | 2-1 | UNAM Pumas | |
CD Motagua 2-5 FC Cincinnati *
| 27.02.2025 | FC Cincinnati | 1-1 | CD Motagua | |
| 20.02.2025 | CD Motagua | 1-4 | FC Cincinnati | |
Cibao FC 1-4 Guadalajara Chivas *
| 13.02.2025 | Guadalajara Chivas | 3-0 | Cibao FC | |
| 07.02.2025 | Cibao FC | 1-1 | Guadalajara Chivas | |
Forge FC 0-5 CF Monterrey *
| 12.02.2025 | CF Monterrey | 3-0 | Forge FC | |
| 06.02.2025 | Forge FC | 0-2 | CF Monterrey | |
Colorado Rapids 2-2 Los Angeles FC *
| 26.02.2025 | Los Angeles FC | 1-0 | Colorado Rapids | |
| 19.02.2025 | Colorado Rapids | 2-1 | Los Angeles FC | |
Real Estelí 1-3 Tigres UANL *
| 13.02.2025 | Tigres UANL | 3-0 | Real Estelí | |
| 06.02.2025 | Real Estelí | 1-0 | Tigres UANL | |
Real Hope FA 0-7 Cruz Azul *
| 12.02.2025 | Cruz Azul | 5-0 | Real Hope FA | |
| 05.02.2025 | Real Hope FA | 0-2 | Cruz Azul | |
*CS Herediano 2-1 Real Salt Lake
| 27.02.2025 | Real Salt Lake | 1-2 | CS Herediano | |
| 20.02.2025 | CS Herediano | 0-0 | Real Salt Lake | |
Sporting Kansas City 1-4 Inter Miami CF *
| 26.02.2025 | Inter Miami CF | 3-1 | Sporting Kansas City | |
| 20.02.2025 | Sporting Kansas City | 0-1 | Inter Miami CF | |
Saprissa 2-3 Vancouver WC *
| 28.02.2025 | Vancouver WC | 2-0 | Saprissa | |
| 21.02.2025 | Saprissa | 2-1 | Vancouver WC | |