Seattle Sounders 0-0 Antigua GFC
| 18.02.2025 | Antigua GFC | - | Seattle Sounders | |
| 04.02.2025 | Seattle Sounders | - | Antigua GFC | |
UNAM Pumas 0-0 Cavalry FC
| 18.02.2025 | Cavalry FC | - | UNAM Pumas | |
| 04.02.2025 | UNAM Pumas | - | Cavalry FC | |
FC Cincinnati 0-0 CD Motagua
| 18.02.2025 | CD Motagua | - | FC Cincinnati | |
| 04.02.2025 | FC Cincinnati | - | CD Motagua | |
Guadalajara Chivas 0-0 Cibao FC
| 18.02.2025 | Cibao FC | - | Guadalajara Chivas | |
| 04.02.2025 | Guadalajara Chivas | - | Cibao FC | |
CF Monterrey 0-0 Forge FC
| 18.02.2025 | Forge FC | - | CF Monterrey | |
| 04.02.2025 | CF Monterrey | - | Forge FC | |
Los Angeles FC 0-0 Colorado Rapids
| 18.02.2025 | Colorado Rapids | - | Los Angeles FC | |
| 04.02.2025 | Los Angeles FC | - | Colorado Rapids | |
Tigres UANL 0-0 Real Estelí
| 18.02.2025 | Real Estelí | - | Tigres UANL | |
| 04.02.2025 | Tigres UANL | - | Real Estelí | |
Cruz Azul 0-0 Real Hope FA
| 18.02.2025 | Real Hope FA | - | Cruz Azul | |
| 04.02.2025 | Cruz Azul | - | Real Hope FA | |
Real Salt Lake 0-0 CS Herediano
| 18.02.2025 | CS Herediano | - | Real Salt Lake | |
| 04.02.2025 | Real Salt Lake | - | CS Herediano | |
Inter Miami CF 0-0 Sporting Kansas City
| 18.02.2025 | Sporting Kansas City | - | Inter Miami CF | |
| 04.02.2025 | Inter Miami CF | - | Sporting Kansas City | |
Vancouver WC 0-0 Saprissa
| 18.02.2025 | Saprissa | - | Vancouver WC | |
| 04.02.2025 | Vancouver WC | - | Saprissa | |