Isidro Metapán 2-9 UNAM Pumas *
| 16.03.2012 | UNAM Pumas | 8-0 | Isidro Metapán | |
| 09.03.2012 | Isidro Metapán | 2-1 | UNAM Pumas | |
Monarcas Morelia 2-7 CF Monterrey *
| 14.03.2012 | CF Monterrey | 4-1 | Monarcas Morelia | |
| 07.03.2012 | Monarcas Morelia | 1-3 | CF Monterrey | |
Seattle Sounders 3-7 Santos Laguna *
| 15.03.2012 | Santos Laguna | 6-1 | Seattle Sounders | |
| 08.03.2012 | Seattle Sounders | 2-1 | Santos Laguna | |
*Toronto FC 4-3 Los Angeles Galaxy
| 15.03.2012 | Los Angeles Galaxy | 1-2 | Toronto FC | |
| 08.03.2012 | Toronto FC | 2-2 | Los Angeles Galaxy | |