Club Xelajú MC 2-4 CF Monterrey *
| 13.03.2013 | CF Monterrey | 1-1 | Club Xelajú MC | |
| 07.03.2013 | Club Xelajú MC | 1-3 | CF Monterrey | |
CS Herediano 1-4 Los Angeles Galaxy *
| 14.03.2013 | Los Angeles Galaxy | 4-1 | CS Herediano | |
| 08.03.2013 | CS Herediano | 0-0 | Los Angeles Galaxy | |
Houston Dynamo 1-3 Santos Laguna *
| 14.03.2013 | Santos Laguna | 3-0 | Houston Dynamo | |
| 06.03.2013 | Houston Dynamo | 1-0 | Santos Laguna | |
Tigres UANL 2-3 Seattle Sounders *
| 13.03.2013 | Seattle Sounders | 3-1 | Tigres UANL | |
| 07.03.2013 | Tigres UANL | 1-0 | Seattle Sounders | |