Club Tijuana 1-5 New York Red Bulls *
| 14.03.2018 | New York Red Bulls | 3-1 | Club Tijuana | |
| 07.03.2018 | Club Tijuana | 0-2 | New York Red Bulls | |
Seattle Sounders 1-3 Guadalajara Chivas *
| 15.03.2018 | Guadalajara Chivas | 3-0 | Seattle Sounders | |
| 08.03.2018 | Seattle Sounders | 1-0 | Guadalajara Chivas | |
*Club América 7-1 Tauro FC
| 15.03.2018 | Tauro FC | 1-3 | Club América | |
| 07.03.2018 | Club América | 4-0 | Tauro FC | |
*Toronto FC 4-4 Tigres UANL
| 14.03.2018 | Tigres UANL | 3-2 | Toronto FC | |
| 08.03.2018 | Toronto FC | 2-1 | Tigres UANL | |