CD Olimpia 1-3 New York Red Bulls *
| 02.03.2018 | New York Red Bulls | 2-0 | CD Olimpia | |
| 23.02.2018 | CD Olimpia | 1-1 | New York Red Bulls | |
CD Motagua 1-2 Club Tijuana *
| 28.02.2018 | Club Tijuana | 1-1 | CD Motagua | |
| 22.02.2018 | CD Motagua | 0-1 | Club Tijuana | |
Colorado Rapids 0-2 Toronto FC *
| 28.02.2018 | Toronto FC | 0-0 | Colorado Rapids | |
| 21.02.2018 | Colorado Rapids | 0-2 | Toronto FC | |
Cibao FC 0-7 Guadalajara Chivas *
| 01.03.2018 | Guadalajara Chivas | 5-0 | Cibao FC | |
| 23.02.2018 | Cibao FC | 0-2 | Guadalajara Chivas | |
Saprissa 2-6 Club América *
| 01.03.2018 | Club América | 1-1 | Saprissa | |
| 22.02.2018 | Saprissa | 1-5 | Club América | |
Santa Tecla FC 2-5 Seattle Sounders *
| 02.03.2018 | Seattle Sounders | 4-0 | Santa Tecla FC | |
| 23.02.2018 | Santa Tecla FC | 2-1 | Seattle Sounders | |
CS Herediano 3-5 Tigres UANL *
| 28.02.2018 | Tigres UANL | 3-1 | CS Herediano | |
| 21.02.2018 | CS Herediano | 2-2 | Tigres UANL | |