AD San Carlos 3-6 New York City FC *
| 27.02.2020 | New York City FC | 1-0 | AD San Carlos | |
| 21.02.2020 | AD San Carlos | 3-5 | New York City FC | |
CD Motagua 1-4 Atlanta United *
| 26.02.2020 | Atlanta United | 3-0 | CD Motagua | |
| 19.02.2020 | CD Motagua | 1-1 | Atlanta United | |
*CD Olimpia 4-4 Seattle Sounders
| 28.02.2020 | Seattle Sounders | 2-2/p.2-4 | CD Olimpia | |
| 21.02.2020 | CD Olimpia | 2-2 | Seattle Sounders | |
Club León 2-3 Los Angeles FC *
| 28.02.2020 | Los Angeles FC | 3-0 | Club León | |
| 19.02.2020 | Club León | 2-0 | Los Angeles FC | |
CSD Comunicaciones 2-2 Club América *
| 27.02.2020 | Club América | 1-1/p.5-3 | CSD Comunicaciones | |
| 20.02.2020 | CSD Comunicaciones | 1-1 | Club América | |
Saprissa 2-2 Montreal Impact *
| 27.02.2020 | Montreal Impact | 0-0 | Saprissa | |
| 20.02.2020 | Saprissa | 2-2 | Montreal Impact | |
Portmore United 1-6 Cruz Azul *
| 26.02.2020 | Cruz Azul | 4-0 | Portmore United | |
| 19.02.2020 | Portmore United | 1-2 | Cruz Azul | |
Alianza FC (SLV) 4-5 Tigres UANL *
| 27.02.2020 | Tigres UANL | 4-2 | Alianza FC (SLV) | |
| 20.02.2020 | Alianza FC (SLV) | 2-1 | Tigres UANL | |