CD Motagua 0-6 Tigres UANL *
| 14.04.2023 | Tigres UANL | 5-0 | CD Motagua | |
| 06.04.2023 | CD Motagua | 0-1 | Tigres UANL | |
*Club León 6-2 Violette AC
| 12.04.2023 | Violette AC | 2-1 | Club León | |
| 05.04.2023 | Club León | 5-0 | Violette AC | |
*Philadelphia Union 3-2 Club Atlas
| 13.04.2023 | Club Atlas | 2-2 | Philadelphia Union | |
| 05.04.2023 | Philadelphia Union | 1-0 | Club Atlas | |
Vancouver WC 0-6 Los Angeles FC *
| 12.04.2023 | Los Angeles FC | 3-0 | Vancouver WC | |
| 06.04.2023 | Vancouver WC | 0-3 | Los Angeles FC | |