*Vélez Sársfield 7-2 Club Libertad
| 18.05.2011 | Club Libertad | 2-4 | Vélez Sársfield | |
| 12.05.2011 | Vélez Sársfield | 3-0 | Club Libertad | |
Jaguares Chiapas 1-2 Cerro Porteño *
| 20.05.2011 | Cerro Porteño | 1-0 | Jaguares Chiapas | |
| 13.05.2011 | Jaguares Chiapas | 1-1 | Cerro Porteño | |
Once Caldas 1-2 Santos/SP *
| 19.05.2011 | Santos/SP | 1-1 | Once Caldas | |
| 12.05.2011 | Once Caldas | 0-1 | Santos/SP | |
*CA Peñarol 3-2 Universidad Católica
| 19.05.2011 | Universidad Católica | 2-1 | CA Peñarol | |
| 11.05.2011 | CA Peñarol | 2-0 | Universidad Católica | |