CA Huracán 2-4 Atlético Nacional *
| 04.05.2016 | Atlético Nacional | 4-2 | CA Huracán | |
| 27.04.2016 | CA Huracán | 0-0 | Atlético Nacional | |
Cerro Porteño 2-5 Boca Juniors *
| 06.05.2016 | Boca Juniors | 3-1 | Cerro Porteño | |
| 29.04.2016 | Cerro Porteño | 1-2 | Boca Juniors | |
Grêmio/RS 0-4 Rosario Central *
| 06.05.2016 | Rosario Central | 3-0 | Grêmio/RS | |
| 28.04.2016 | Grêmio/RS | 0-1 | Rosario Central | |
*Independiente del Valle 2-1 River Plate
| 05.05.2016 | River Plate | 1-0 | Independiente del Valle | |
| 29.04.2016 | Independiente del Valle | 2-0 | River Plate | |
*Nacional (URU) 2-2 Corinthians/SP
| 05.05.2016 | Corinthians/SP | 2-2 | Nacional (URU) | |
| 28.04.2016 | Nacional (URU) | 0-0 | Corinthians/SP | |
Racing Club 1-2 Atlético Mineiro/MG *
| 05.05.2016 | Atlético Mineiro/MG | 2-1 | Racing Club | |
| 28.04.2016 | Racing Club | 0-0 | Atlético Mineiro/MG | |
*São Paulo/SP 5-3 Deportivo Toluca
| 05.05.2016 | Deportivo Toluca | 3-1 | São Paulo/SP | |
| 29.04.2016 | São Paulo/SP | 4-0 | Deportivo Toluca | |
Deportivo Tachira 1-2 UNAM Pumas *
| 04.05.2016 | UNAM Pumas | 2-0 | Deportivo Tachira | |
| 27.04.2016 | Deportivo Tachira | 1-0 | UNAM Pumas | |