*CA Huracán 2-2 Caracas FC
| 10.02.2016 | Caracas FC | 2-1 | CA Huracán | |
| 02.02.2016 | CA Huracán | 1-0 | Caracas FC | |
Cesar Vallejo 1-2 São Paulo/SP *
| 11.02.2016 | São Paulo/SP | 1-0 | Cesar Vallejo | |
| 04.02.2016 | Cesar Vallejo | 1-1 | São Paulo/SP | |
Oriente Petrolero 1-6 Ind. Santa Fe *
| 12.02.2016 | Ind. Santa Fe | 3-0 | Oriente Petrolero | |
| 05.02.2016 | Oriente Petrolero | 1-3 | Ind. Santa Fe | |
*Independiente del Valle 2-2 Club Guaraní
| 11.02.2016 | Club Guaraní | 2-1 | Independiente del Valle | |
| 04.02.2016 | Independiente del Valle | 1-0 | Club Guaraní | |
Puebla FC 2-3 Racing Club *
| 11.02.2016 | Racing Club | 1-0 | Puebla FC | |
| 04.02.2016 | Puebla FC | 2-2 | Racing Club | |
*River Plate (URU) 2-0 Univ de Chile
| 09.02.2016 | Univ de Chile | 0-0 | River Plate (URU) | |
| 03.02.2016 | River Plate (URU) | 2-0 | Univ de Chile | |