Atlético Tucumán 0-6 Grêmio/RS *
| 03.10.2018 | Grêmio/RS | 4-0 | Atlético Tucumán | |
| 19.09.2018 | Atlético Tucumán | 0-2 | Grêmio/RS | |
*Boca Juniors 3-1 Cruzeiro/MG
| 05.10.2018 | Cruzeiro/MG | 1-1 | Boca Juniors | |
| 20.09.2018 | Boca Juniors | 2-0 | Cruzeiro/MG | |
Independiente 1-3 River Plate *
| 03.10.2018 | River Plate | 3-1 | Independiente | |
| 20.09.2018 | Independiente | 0-0 | River Plate | |
Colo Colo 0-4 Palmeiras/SP *
| 04.10.2018 | Palmeiras/SP | 2-0 | Colo Colo | |
| 21.09.2018 | Colo Colo | 0-2 | Palmeiras/SP | |