Athletico/PR 1-2 River Plate *
| 01.12.2020 | River Plate | 1-0 | Athletico/PR | |
| 24.11.2020 | Athletico/PR | 1-1 | River Plate | |
Club Guaraní 0-4 Grêmio/RS *
| 04.12.2020 | Grêmio/RS | 2-0 | Club Guaraní | |
| 27.11.2020 | Club Guaraní | 0-2 | Grêmio/RS | |
*Club Libertad 5-1 Jorge Wilstermann
| 03.12.2020 | Jorge Wilstermann | 0-2 | Club Libertad | |
| 26.11.2020 | Club Libertad | 3-1 | Jorge Wilstermann | |
Delfin SC 1-8 Palmeiras/SP *
| 02.12.2020 | Palmeiras/SP | 5-0 | Delfin SC | |
| 25.11.2020 | Delfin SC | 1-3 | Palmeiras/SP | |
Independiente del Valle 0-0 Nacional (URU) *
| 02.12.2020 | Nacional (URU) | 0-0/p.4-2 | Independiente del Valle | |
| 25.11.2020 | Independiente del Valle | 0-0 | Nacional (URU) | |
Internacional/RS 1-1 Boca Juniors *
| 10.12.2020 | Boca Juniors | 0-1/p.5-4 | Internacional/RS | |
| 03.12.2020 | Internacional/RS | 0-1 | Boca Juniors | |
*Racing Club 2-2 Flamengo/RJ
| 02.12.2020 | Flamengo/RJ | 1-1/p.3-5 | Racing Club | |
| 25.11.2020 | Racing Club | 1-1 | Flamengo/RJ | |