Boca Juniors 0-0 Atlético Mineiro/MG *
| 21.07.2021 | Atlético Mineiro/MG | 0-0/p.3-1 | Boca Juniors | |
| 14.07.2021 | Boca Juniors | 0-0 | Atlético Mineiro/MG | |
Vélez Sársfield 2-3 Barcelona SC *
| 22.07.2021 | Barcelona SC | 3-1 | Vélez Sársfield | |
| 15.07.2021 | Vélez Sársfield | 1-0 | Barcelona SC | |
Cerro Porteño 0-3 Fluminense/RJ *
| 04.08.2021 | Fluminense/RJ | 1-0 | Cerro Porteño | |
| 14.07.2021 | Cerro Porteño | 0-2 | Fluminense/RJ | |
Defensa y Justicia 1-5 Flamengo/RJ *
| 22.07.2021 | Flamengo/RJ | 4-1 | Defensa y Justicia | |
| 15.07.2021 | Defensa y Justicia | 0-1 | Flamengo/RJ | |
*Olimpia Asunción 0-0 Internacional/RS
| 23.07.2021 | Internacional/RS | 0-0/p.4-5 | Olimpia Asunción | |
| 16.07.2021 | Olimpia Asunción | 0-0 | Internacional/RS | |
*São Paulo/SP 4-2 Racing Club
| 21.07.2021 | Racing Club | 1-3 | São Paulo/SP | |
| 14.07.2021 | São Paulo/SP | 1-1 | Racing Club | |
*River Plate 3-1 Argentinos Juniors
| 22.07.2021 | Argentinos Juniors | 0-2 | River Plate | |
| 15.07.2021 | River Plate | 1-1 | Argentinos Juniors | |
Universidad Católica 0-2 Palmeiras/SP *
| 22.07.2021 | Palmeiras/SP | 1-0 | Universidad Católica | |
| 15.07.2021 | Universidad Católica | 0-1 | Palmeiras/SP | |