Bolívar 2-4 Junior Barranquilla *
| 16.04.2021 | Junior Barranquilla | 3-0 | Bolívar | |
| 09.04.2021 | Bolívar | 2-1 | Junior Barranquilla | |
Club Libertad 2-4 Atlético Nacional *
| 15.04.2021 | Atlético Nacional | 4-1 | Club Libertad | |
| 08.04.2021 | Club Libertad | 1-0 | Atlético Nacional | |
*Independiente del Valle 4-2 Grêmio/RS
| 15.04.2021 | Grêmio/RS | 1-2 | Independiente del Valle | |
| 10.04.2021 | Independiente del Valle | 2-1 | Grêmio/RS | |
San Lorenzo 3-5 Santos/SP *
| 14.04.2021 | Santos/SP | 2-2 | San Lorenzo | |
| 07.04.2021 | San Lorenzo | 1-3 | Santos/SP | |