Fluminense/RJ 3-3 Barcelona SC *
| 20.08.2021 | Barcelona SC | 1-1 | Fluminense/RJ | |
| 13.08.2021 | Fluminense/RJ | 2-2 | Barcelona SC | |
Olimpia Asunción 2-9 Flamengo/RJ *
| 19.08.2021 | Flamengo/RJ | 5-1 | Olimpia Asunción | |
| 12.08.2021 | Olimpia Asunción | 1-4 | Flamengo/RJ | |
River Plate 0-4 Atlético Mineiro/MG *
| 19.08.2021 | Atlético Mineiro/MG | 3-0 | River Plate | |
| 12.08.2021 | River Plate | 0-1 | Atlético Mineiro/MG | |
São Paulo/SP 1-4 Palmeiras/SP *
| 18.08.2021 | Palmeiras/SP | 3-0 | São Paulo/SP | |
| 11.08.2021 | São Paulo/SP | 1-1 | Palmeiras/SP | |