The Strongest 1-4 Bahia/BA *
| 26.02.2025 | Bahia/BA | 3-0 | The Strongest | |
| 19.02.2025 | The Strongest | 1-1 | Bahia/BA | |
*Alianza Lima 2-2 Boca Juniors
| 26.02.2025 | Boca Juniors | 2-1/p.4-5 | Alianza Lima | |
| 19.02.2025 | Alianza Lima | 1-0 | Boca Juniors | |
*Boston River 2-1 Ñublense
| 26.02.2025 | Ñublense | 1-1 | Boston River | |
| 19.02.2025 | Boston River | 1-0 | Ñublense | |
UCV FC 3-4 Corinthians/SP *
| 27.02.2025 | Corinthians/SP | 3-2 | UCV FC | |
| 20.02.2025 | UCV FC | 1-1 | Corinthians/SP | |
*Deportes Iquique 3-3 Ind. Santa Fe
| 25.02.2025 | Ind. Santa Fe | 2-1/p.1-2 | Deportes Iquique | |
| 18.02.2025 | Deportes Iquique | 2-1 | Ind. Santa Fe | |
Deportes Tolima 0-2 FBC Melgar *
| 28.02.2025 | FBC Melgar | 1-0 | Deportes Tolima | |
| 21.02.2025 | Deportes Tolima | 0-1 | FBC Melgar | |
El Nacional Quito 1-2 Barcelona SC *
| 27.02.2025 | Barcelona SC | 1-1 | El Nacional Quito | |
| 20.02.2025 | El Nacional Quito | 0-1 | Barcelona SC | |
Monagas SC 1-7 Cerro Porteño *
| 27.02.2025 | Cerro Porteño | 3-1 | Monagas SC | |
| 20.02.2025 | Monagas SC | 0-4 | Cerro Porteño | |