Deportivo Cali 2-2 Atlético Nacional *
| 24.08.2005 | Atlético Nacional | 2-0/p.7-6 | Deportivo Cali | |
| 17.08.2005 | Deportivo Cali | 2-0 | Atlético Nacional | |
*The Strongest 4-2 Bolívar
| 26.08.2005 | Bolívar | 1-2 | The Strongest | |
| 12.08.2005 | The Strongest | 2-1 | Bolívar | |
Club Guaraní 3-3 Cerro Porteño *
| 24.08.2005 | Cerro Porteño | 1-2/p.4-3 | Club Guaraní | |
| 10.08.2005 | Club Guaraní | 1-2 | Cerro Porteño | |
Goiás/GO 1-3 Corinthians/SP *
| 01.09.2005 | Corinthians/SP | 1-1 | Goiás/GO | |
| 18.08.2005 | Goiás/GO | 0-2 | Corinthians/SP | |
*Defensor Sporting 5-4 Danubio FC
| 23.08.2005 | Danubio FC | 1-3 | Defensor Sporting | |
| 17.08.2005 | Defensor Sporting | 2-3 | Danubio FC | |
El Nacional Quito 5-5 LDU Quito *
| 26.08.2005 | LDU Quito | 1-2 | El Nacional Quito | |
| 10.08.2005 | El Nacional Quito | 3-4 | LDU Quito | |
*CA Banfield 3-2 Estudiantes La Plata
| 26.08.2005 | Estudiantes La Plata | 2-1 | CA Banfield | |
| 11.08.2005 | CA Banfield | 2-0 | Estudiantes La Plata | |
Juventude/RS 2-3 Cruzeiro/MG *
| 02.09.2005 | Cruzeiro/MG | 0-1 | Juventude/RS | |
| 18.08.2005 | Juventude/RS | 1-3 | Cruzeiro/MG | |
*Trujillanos FC 5-2 Mineros Guyana
| 24.08.2005 | Mineros Guyana | 1-2 | Trujillanos FC | |
| 19.08.2005 | Trujillanos FC | 3-1 | Mineros Guyana | |
Newell's Old Boys 0-1 Rosario Central *
| 30.08.2005 | Rosario Central | 1-0 | Newell's Old Boys | |
| 19.08.2005 | Newell's Old Boys | 0-0 | Rosario Central | |
*Fluminense/RJ 3-3 Santos/SP
| 01.09.2005 | Santos/SP | 2-1/p.2-4 | Fluminense/RJ | |
| 18.08.2005 | Fluminense/RJ | 2-1 | Santos/SP | |
*Internacional/RS 3-2 São Paulo/SP
| 02.09.2005 | São Paulo/SP | 1-1 | Internacional/RS | |
| 18.08.2005 | Internacional/RS | 2-1 | São Paulo/SP | |
Univ de Chile 2-2 Universidad Católica *
| 26.08.2005 | Universidad Católica | 0-1 | Univ de Chile | |
| 12.08.2005 | Univ de Chile | 1-2 | Universidad Católica | |
Universitario 2-2 Alianza Atlético *
| 24.08.2005 | Alianza Atlético | 1-1/p.3-0 | Universitario | |
| 11.08.2005 | Universitario | 1-1 | Alianza Atlético | |