Boca Juniors 2-2 São Paulo/SP *
| 27.09.2007 | São Paulo/SP | 1-0 | Boca Juniors | |
| 20.09.2007 | Boca Juniors | 2-1 | São Paulo/SP | |
CA Lanús 2-3 Vasco da Gama/RJ *
| 27.09.2007 | Vasco da Gama/RJ | 3-0 | CA Lanús | |
| 20.09.2007 | CA Lanús | 2-0 | Vasco da Gama/RJ | |
*Millonarios 2-2 Colo Colo
| 05.10.2007 | Colo Colo | 1-1/p.6-7 | Millonarios | |
| 26.09.2007 | Millonarios | 1-1 | Colo Colo | |
*Defensor Sporting 3-2 El Nacional Quito
| 05.10.2007 | El Nacional Quito | 2-0 | Defensor Sporting | |
| 21.09.2007 | Defensor Sporting | 3-0 | El Nacional Quito | |
Goiás/GO 3-4 Arsenal Sarandi *
| 27.09.2007 | Arsenal Sarandi | 1-1 | Goiás/GO | |
| 19.09.2007 | Goiás/GO | 2-3 | Arsenal Sarandi | |
DC United 2-2 Guadalajara Chivas *
| 03.10.2007 | Guadalajara Chivas | 1-0 | DC United | |
| 27.09.2007 | DC United | 2-1 | Guadalajara Chivas | |
Pachuca CF 3-4 Club América *
| 04.10.2007 | Club América | 0-2 | Pachuca CF | |
| 26.09.2007 | Pachuca CF | 1-4 | Club América | |
Botafogo/RJ 3-4 River Plate *
| 28.09.2007 | River Plate | 4-2 | Botafogo/RJ | |
| 20.09.2007 | Botafogo/RJ | 1-0 | River Plate | |