*Goiás/GO 3-2 Avai FC/SC
| 11.11.2010 | Avai FC/SC | 0-1 | Goiás/GO | |
| 28.10.2010 | Goiás/GO | 2-2 | Avai FC/SC | |
Deportes Tolima 2-2 Independiente *
| 12.11.2010 | Independiente | 0-0 | Deportes Tolima | |
| 04.11.2010 | Deportes Tolima | 2-2 | Independiente | |
Newell's Old Boys 0-1 LDU Quito *
| 11.11.2010 | LDU Quito | 1-0 | Newell's Old Boys | |
| 03.11.2010 | Newell's Old Boys | 0-0 | LDU Quito | |
Atlético Mineiro/MG 1-3 Palmeiras/SP *
| 11.11.2010 | Palmeiras/SP | 2-0 | Atlético Mineiro/MG | |
| 27.10.2010 | Atlético Mineiro/MG | 1-1 | Palmeiras/SP | |