*Independiente 2-1 Argentinos Juniors
| 10.09.2010 | Argentinos Juniors | 1-1 | Independiente | |
| 27.08.2010 | Independiente | 1-0 | Argentinos Juniors | |
Grêmio Prudente/SP 0-1 Atlético Mineiro/MG *
| 12.08.2010 | Atlético Mineiro/MG | 1-0 | Grêmio Prudente/SP | |
| 05.08.2010 | Grêmio Prudente/SP | 0-0 | Atlético Mineiro/MG | |
Barcelona SC 1-3 CA Peñarol *
| 15.09.2010 | CA Peñarol | 2-1 | Barcelona SC | |
| 01.09.2010 | Barcelona SC | 0-1 | CA Peñarol | |
Atlético Huila 1-5 CD San José *
| 23.09.2010 | CD San José | 4-0 | Atlético Huila | |
| 08.09.2010 | Atlético Huila | 1-1 | CD San José | |
*Universitario Sucre 3-2 Cerro Porteño
| 22.09.2010 | Cerro Porteño | 2-2 | Universitario Sucre | |
| 10.09.2010 | Universitario Sucre | 1-0 | Cerro Porteño | |
Club Guaraní 2-2 Unión San Felipe *
| 24.09.2010 | Unión San Felipe | 1-1/p.8-7 | Club Guaraní | |
| 08.09.2010 | Club Guaraní | 1-1 | Unión San Felipe | |
*Club Santa Fe 2-1 Caracas FC
| 24.09.2010 | Caracas FC | 0-0 | Club Santa Fe | |
| 17.09.2010 | Club Santa Fe | 2-1 | Caracas FC | |
Univ San Martín 2-6 CS Emelec *
| 24.09.2010 | CS Emelec | 5-0 | Univ San Martín | |
| 16.09.2010 | Univ San Martín | 2-1 | CS Emelec | |
Defensor Sporting 9-2 Sport Huancayo
| 22.09.2010 | Sport Huancayo | 2-0 | Defensor Sporting | |
| 17.09.2010 | Defensor Sporting | 9-0 | Sport Huancayo | |
Oriente Petrolero 1-2 Deportes Tolima *
| 22.09.2010 | Deportes Tolima | 2-0 | Oriente Petrolero | |
| 15.09.2010 | Oriente Petrolero | 1-0 | Deportes Tolima | |
*Newell's Old Boys 2-1 Estudiantes La Plata
| 23.09.2010 | Estudiantes La Plata | 1-1 | Newell's Old Boys | |
| 17.09.2010 | Newell's Old Boys | 1-0 | Estudiantes La Plata | |
Vitória/BA 2-3 Palmeiras/SP *
| 20.08.2010 | Palmeiras/SP | 3-0 | Vitória/BA | |
| 12.08.2010 | Vitória/BA | 2-0 | Palmeiras/SP | |
Santos/SP 2-3 Avai FC/SC *
| 19.08.2010 | Avai FC/SC | 0-1 | Santos/SP | |
| 13.08.2010 | Santos/SP | 1-3 | Avai FC/SC | |
Vélez Sársfield 1-2 CA Banfield *
| 16.09.2010 | CA Banfield | 1-1 | Vélez Sársfield | |
| 03.09.2010 | Vélez Sársfield | 0-1 | CA Banfield | |