*Atlético Mineiro/MG 2-1 Club Santa Fe
| 21.10.2010 | Club Santa Fe | 1-0 | Atlético Mineiro/MG | |
| 14.10.2010 | Atlético Mineiro/MG | 2-0 | Club Santa Fe | |
CS Emelec 3-4 Avai FC/SC *
| 22.10.2010 | Avai FC/SC | 3-1 | CS Emelec | |
| 14.10.2010 | CS Emelec | 2-1 | Avai FC/SC | |
Defensor Sporting 3-4 Independiente *
| 20.10.2010 | Independiente | 4-2 | Defensor Sporting | |
| 29.09.2010 | Defensor Sporting | 1-0 | Independiente | |
CA Banfield 2-3 Deportes Tolima *
| 13.10.2010 | Deportes Tolima | 3-0 | CA Banfield | |
| 30.09.2010 | CA Banfield | 2-0 | Deportes Tolima | |
*Goiás/GO 3-3 CA Peñarol
| 20.10.2010 | CA Peñarol | 3-2 | Goiás/GO | |
| 14.10.2010 | Goiás/GO | 1-0 | CA Peñarol | |
*Newell's Old Boys 6-2 CD San José
| 22.10.2010 | CD San José | 2-0 | Newell's Old Boys | |
| 07.10.2010 | Newell's Old Boys | 6-0 | CD San José | |
Universitario Sucre 1-4 Palmeiras/SP *
| 21.10.2010 | Palmeiras/SP | 3-1 | Universitario Sucre | |
| 15.10.2010 | Universitario Sucre | 0-1 | Palmeiras/SP | |
Unión San Felipe 5-8 LDU Quito *
| 20.10.2010 | LDU Quito | 6-1 | Unión San Felipe | |
| 13.10.2010 | Unión San Felipe | 4-2 | LDU Quito | |