Atlético/PR 1-2 Sportivo Luqueño *
| 28.10.2015 | Sportivo Luqueño | 2-0 | Atlético/PR | |
| 22.10.2015 | Atlético/PR | 1-0 | Sportivo Luqueño | |
*CA Huracán 1-0 Defensor Sporting
| 28.10.2015 | Defensor Sporting | 0-0 | CA Huracán | |
| 21.10.2015 | CA Huracán | 1-0 | Defensor Sporting | |
Independiente 1-2 Ind. Santa Fe *
| 30.10.2015 | Ind. Santa Fe | 1-1 | Independiente | |
| 23.10.2015 | Independiente | 0-1 | Ind. Santa Fe | |
*River Plate 4-3 Chapecoense/SC
| 29.10.2015 | Chapecoense/SC | 2-1 | River Plate | |
| 22.10.2015 | River Plate | 3-1 | Chapecoense/SC | |