Coritiba/PR 2-4 Atlético Nacional *
| 27.10.2016 | Atlético Nacional | 3-1 | Coritiba/PR | |
| 20.10.2016 | Coritiba/PR | 1-1 | Atlético Nacional | |
Independiente Medellín 0-2 Cerro Porteño *
| 26.10.2016 | Cerro Porteño | 2-0 | Independiente Medellín | |
| 19.10.2016 | Independiente Medellín | 0-0 | Cerro Porteño | |
Junior Barranquilla 1-3 Chapecoense/SC *
| 27.10.2016 | Chapecoense/SC | 3-0 | Junior Barranquilla | |
| 20.10.2016 | Junior Barranquilla | 1-0 | Chapecoense/SC | |
*San Lorenzo 2-1 CD Palestino
| 28.10.2016 | CD Palestino | 1-0 | San Lorenzo | |
| 21.10.2016 | San Lorenzo | 2-0 | CD Palestino | |