Bolívar 1-2 Atlético Nacional *
| 14.09.2016 | Atlético Nacional | 1-0 | Bolívar | |
| 25.08.2016 | Bolívar | 1-1 | Atlético Nacional | |
Estudiantes La Plata 1-2 Belgrano Córdoba *
| 16.09.2016 | Belgrano Córdoba | 2-0 | Estudiantes La Plata | |
| 25.08.2016 | Estudiantes La Plata | 1-0 | Belgrano Córdoba | |
Blooming 1-3 Junior Barranquilla *
| 15.09.2016 | Junior Barranquilla | 1-1 | Blooming | |
| 24.08.2016 | Blooming | 0-2 | Junior Barranquilla | |
CA Banfield 3-4 San Lorenzo *
| 14.09.2016 | San Lorenzo | 4-1 | CA Banfield | |
| 24.08.2016 | CA Banfield | 2-0 | San Lorenzo | |
Cuiabá/MT 2-3 Chapecoense/SC *
| 01.09.2016 | Chapecoense/SC | 3-1 | Cuiabá/MT | |
| 26.08.2016 | Cuiabá/MT | 1-0 | Chapecoense/SC | |
*Deportivo La Guaira 4-2 CS Emelec
| 14.09.2016 | CS Emelec | 0-0 | Deportivo La Guaira | |
| 24.08.2016 | Deportivo La Guaira | 4-2 | CS Emelec | |
Figueirense/SC 5-5 Flamengo/RJ *
| 01.09.2016 | Flamengo/RJ | 3-1 | Figueirense/SC | |
| 25.08.2016 | Figueirense/SC | 4-2 | Flamengo/RJ | |
CA Lanús 0-3 Independiente *
| 15.09.2016 | Independiente | 1-0 | CA Lanús | |
| 26.08.2016 | CA Lanús | 0-2 | Independiente | |
Real Garcilaso 2-3 CD Palestino *
| 16.09.2016 | CD Palestino | 1-0 | Real Garcilaso | |
| 24.08.2016 | Real Garcilaso | 2-2 | CD Palestino | |
*Cerro Porteño 7-0 Real Potosí
| 16.09.2016 | Real Potosí | 0-1 | Cerro Porteño | |
| 25.08.2016 | Cerro Porteño | 6-0 | Real Potosí | |
*Santa Cruz/PE 1-0 Sport Recife/PE
| 01.09.2016 | Sport Recife/PE | 0-1 | Santa Cruz/PE | |
| 25.08.2016 | Santa Cruz/PE | 0-0 | Sport Recife/PE | |
*Sol de América 2-1 Sport Huancayo
| 15.09.2016 | Sport Huancayo | 1-1 | Sol de América | |
| 26.08.2016 | Sol de América | 1-0 | Sport Huancayo | |
*Independiente Medellín 3-2 Sportivo Luqueño
| 16.09.2016 | Sportivo Luqueño | 2-0 | Independiente Medellín | |
| 25.08.2016 | Independiente Medellín | 3-0 | Sportivo Luqueño | |
Vitória/BA 2-2 Coritiba/PR *
| 31.08.2016 | Coritiba/PR | 1-0 | Vitória/BA | |
| 26.08.2016 | Vitória/BA | 2-1 | Coritiba/PR | |
Zamora FC 0-2 Mvo Wanderers *
| 14.09.2016 | Mvo Wanderers | 1-0 | Zamora FC | |
| 26.08.2016 | Zamora FC | 0-1 | Mvo Wanderers | |