*Coritiba/PR 3-3 Belgrano Córdoba
| 29.09.2016 | Belgrano Córdoba | 1-2/p.3-4 | Coritiba/PR | |
| 22.09.2016 | Coritiba/PR | 1-2 | Belgrano Córdoba | |
Independiente 0-0 Chapecoense/SC *
| 29.09.2016 | Chapecoense/SC | 0-0/p.5-4 | Independiente | |
| 22.09.2016 | Independiente | 0-0 | Chapecoense/SC | |
*San Lorenzo 4-1 Deportivo La Guaira
| 30.09.2016 | Deportivo La Guaira | 0-2 | San Lorenzo | |
| 23.09.2016 | San Lorenzo | 2-1 | Deportivo La Guaira | |
*CD Palestino 2-2 Flamengo/RJ
| 29.09.2016 | Flamengo/RJ | 1-2 | CD Palestino | |
| 22.09.2016 | CD Palestino | 0-1 | Flamengo/RJ | |
Ind. Santa Fe 3-4 Cerro Porteño *
| 30.09.2016 | Cerro Porteño | 4-1 | Ind. Santa Fe | |
| 23.09.2016 | Ind. Santa Fe | 2-0 | Cerro Porteño | |
*Independiente Medellín 3-3 Santa Cruz/PE
| 29.09.2016 | Santa Cruz/PE | 3-1 | Independiente Medellín | |
| 22.09.2016 | Independiente Medellín | 2-0 | Santa Cruz/PE | |
Mvo Wanderers 0-0 Junior Barranquilla *
| 29.09.2016 | Junior Barranquilla | 0-0/p.4-3 | Mvo Wanderers | |
| 22.09.2016 | Mvo Wanderers | 0-0 | Junior Barranquilla | |
Sol de América 1-3 Atlético Nacional *
| 28.09.2016 | Atlético Nacional | 2-0 | Sol de América | |
| 21.09.2016 | Sol de América | 1-1 | Atlético Nacional | |