Nacional Asunción 2-3 Botafogo/RJ *
| 17.08.2018 | Botafogo/RJ | 2-0 | Nacional Asunción | |
| 02.08.2018 | Nacional Asunción | 2-1 | Botafogo/RJ | |
Boston River 1-2 CA Banfield *
| 02.08.2018 | CA Banfield | 2-0 | Boston River | |
| 26.07.2018 | Boston River | 1-0 | CA Banfield | |
*Atlético/PR 6-1 CA Peñarol
| 08.08.2018 | CA Peñarol | 1-4 | Atlético/PR | |
| 27.07.2018 | Atlético/PR | 2-0 | CA Peñarol | |
*Caracas FC 6-3 Sport Huancayo
| 25.07.2018 | Sport Huancayo | 3-4 | Caracas FC | |
| 18.07.2018 | Caracas FC | 2-0 | Sport Huancayo | |
*Fluminense/RJ 3-0 Defensor Sporting
| 17.08.2018 | Defensor Sporting | 0-1 | Fluminense/RJ | |
| 03.08.2018 | Fluminense/RJ | 2-0 | Defensor Sporting | |
*Deportivo Cali 6-1 Bolívar
| 03.08.2018 | Bolívar | 1-2 | Deportivo Cali | |
| 19.07.2018 | Deportivo Cali | 4-0 | Bolívar | |
*Deportivo Cuenca 4-4 Jorge Wilstermann
| 01.08.2018 | Jorge Wilstermann | 2-2/p.5-6 | Deportivo Cuenca | |
| 20.07.2018 | Deportivo Cuenca | 2-2 | Jorge Wilstermann | |
*Defensa y Justicia 2-1 El Nacional Quito
| 01.08.2018 | El Nacional Quito | 1-0 | Defensa y Justicia | |
| 19.07.2018 | Defensa y Justicia | 2-0 | El Nacional Quito | |
General Díaz 1-5 Millonarios *
| 16.08.2018 | Millonarios | 4-0 | General Díaz | |
| 27.07.2018 | General Díaz | 1-1 | Millonarios | |
Rampla Juniors 0-2 Ind. Santa Fe *
| 01.08.2018 | Ind. Santa Fe | 2-0 | Rampla Juniors | |
| 20.07.2018 | Rampla Juniors | 0-0 | Ind. Santa Fe | |
CA Lanús 1-1 Junior Barranquilla *
| 25.07.2018 | Junior Barranquilla | 1-0/p.3-2 | CA Lanús | |
| 18.07.2018 | CA Lanús | 1-0 | Junior Barranquilla | |
*San Lorenzo 3-1 Deportes Temuco
| 16.08.2018 | Deportes Temuco | 1-0 | San Lorenzo | |
| 27.07.2018 | San Lorenzo | 3-0 W.O. | Deportes Temuco | |
São Paulo/SP 1-1 Colon Santa Fe *
| 17.08.2018 | Colon Santa Fe | 0-1/p.5-3 | São Paulo/SP | |
| 03.08.2018 | São Paulo/SP | 0-1 | Colon Santa Fe | |
Sol de América 0-1 Nacional (URU) *
| 15.08.2018 | Nacional (URU) | 1-0 | Sol de América | |
| 19.07.2018 | Sol de América | 0-0 | Nacional (URU) | |
*LDU Quito 3-2 Vasco da Gama/RJ
| 10.08.2018 | Vasco da Gama/RJ | 1-0 | LDU Quito | |
| 26.07.2018 | LDU Quito | 3-1 | Vasco da Gama/RJ | |