*Sporting Cristal 3-2 Arsenal Sarandi
| 22.07.2021 | Arsenal Sarandi | 1-1 | Sporting Cristal | |
| 15.07.2021 | Sporting Cristal | 2-1 | Arsenal Sarandi | |
América de Cali 1-5 Athletico/PR *
| 21.07.2021 | Athletico/PR | 4-1 | América de Cali | |
| 14.07.2021 | América de Cali | 0-1 | Athletico/PR | |
Nacional (URU) 2-2 CA Peñarol *
| 23.07.2021 | CA Peñarol | 0-1 | Nacional (URU) | |
| 16.07.2021 | Nacional (URU) | 1-2 | CA Peñarol | |
Independiente del Valle 1-3 RB Bragantino/SP *
| 22.07.2021 | RB Bragantino/SP | 1-1 | Independiente del Valle | |
| 15.07.2021 | Independiente del Valle | 0-2 | RB Bragantino/SP | |
Junior Barranquilla 4-4 Club Libertad *
| 22.07.2021 | Club Libertad | 0-1 | Junior Barranquilla | |
| 15.07.2021 | Junior Barranquilla | 3-4 | Club Libertad | |
Deportivo Tachira 2-3 Rosario Central *
| 23.07.2021 | Rosario Central | 1-0 | Deportivo Tachira | |
| 16.07.2021 | Deportivo Tachira | 2-2 | Rosario Central | |
*Santos/SP 2-1 Independiente
| 23.07.2021 | Independiente | 1-1 | Santos/SP | |
| 16.07.2021 | Santos/SP | 1-0 | Independiente | |