Santos/SP 2-2 Club Libertad *
| 20.08.2021 | Club Libertad | 1-0 | Santos/SP | |
| 13.08.2021 | Santos/SP | 2-1 | Club Libertad | |
LDU Quito 3-4 Athletico/PR *
| 20.08.2021 | Athletico/PR | 4-2 | LDU Quito | |
| 13.08.2021 | LDU Quito | 1-0 | Athletico/PR | |
Rosario Central 3-5 RB Bragantino/SP *
| 18.08.2021 | RB Bragantino/SP | 1-0 | Rosario Central | |
| 11.08.2021 | Rosario Central | 3-4 | RB Bragantino/SP | |
Sporting Cristal 1-4 CA Peñarol *
| 19.08.2021 | CA Peñarol | 1-0 | Sporting Cristal | |
| 12.08.2021 | Sporting Cristal | 1-3 | CA Peñarol | |