Levski Sofia 1-2 BATE Borisov *
| 27.08.2008 | BATE Borisov | 1-1 | Levski Sofia | |
| 13.08.2008 | Levski Sofia | 0-1 | BATE Borisov | |
Spartak Moscow 2-8 Dynamo Kyiv *
| 27.08.2008 | Dynamo Kyiv | 4-1 | Spartak Moscow | |
| 13.08.2008 | Spartak Moscow | 1-4 | Dynamo Kyiv | |
*AaB Aalborg 4-0 FBK Kaunas
| 27.08.2008 | FBK Kaunas | 0-2 | AaB Aalborg | |
| 13.08.2008 | AaB Aalborg | 2-0 | FBK Kaunas | |
FC Twente 0-6 Arsenal FC *
| 27.08.2008 | Arsenal FC | 4-0 | FC Twente | |
| 13.08.2008 | FC Twente | 0-2 | Arsenal FC | |
*Fiorentina 2-0 Slavia Praha
| 27.08.2008 | Slavia Praha | 0-0 | Fiorentina | |
| 12.08.2008 | Fiorentina | 2-0 | Slavia Praha | |
FK Partizan 3-4 Fenerbahçe SK *
| 27.08.2008 | Fenerbahçe SK | 2-1 | FK Partizan | |
| 13.08.2008 | FK Partizan | 2-2 | Fenerbahçe SK | |
Galatasaray SK 2-3 Steaua Bucuresti *
| 27.08.2008 | Steaua Bucuresti | 1-0 | Galatasaray SK | |
| 13.08.2008 | Galatasaray SK | 2-2 | Steaua Bucuresti | |
*Juventus FC 5-1 FC Artmedia Petržalka
| 26.08.2008 | FC Artmedia Petržalka | 1-1 | Juventus FC | |
| 13.08.2008 | Juventus FC | 4-0 | FC Artmedia Petržalka | |
*Anorthosis FC 3-1 Olympiakos Pireus
| 27.08.2008 | Olympiakos Pireus | 1-0 | Anorthosis FC | |
| 13.08.2008 | Anorthosis FC | 3-0 | Olympiakos Pireus | |
Sparta Praha 1-3 Panathinaikos *
| 26.08.2008 | Panathinaikos | 1-0 | Sparta Praha | |
| 13.08.2008 | Sparta Praha | 1-2 | Panathinaikos | |
Schalke 04 1-4 Atlético Madrid *
| 27.08.2008 | Atlético Madrid | 4-0 | Schalke 04 | |
| 13.08.2008 | Schalke 04 | 1-0 | Atlético Madrid | |
*Shakhtar Donetsk 5-1 Dinamo Zagreb
| 27.08.2008 | Dinamo Zagreb | 1-3 | Shakhtar Donetsk | |
| 13.08.2008 | Shakhtar Donetsk | 2-0 | Dinamo Zagreb | |
SK Brann 1-3 Olympique Marseille *
| 27.08.2008 | Olympique Marseille | 2-1 | SK Brann | |
| 13.08.2008 | SK Brann | 0-1 | Olympique Marseille | |
Standard Liège 0-1 Liverpool *
| 27.08.2008 | Liverpool | 1-0 AET | Standard Liège | |
| 13.08.2008 | Standard Liège | 0-0 | Liverpool | |
Vitória Guimarães 1-2 FC Basel *
| 27.08.2008 | FC Basel | 2-1 | Vitória Guimarães | |
| 13.08.2008 | Vitória Guimarães | 0-0 | FC Basel | |
*FC Barcelona 4-1 Wisła Kraków
| 26.08.2008 | Wisła Kraków | 1-0 | FC Barcelona | |
| 13.08.2008 | FC Barcelona | 4-0 | Wisła Kraków | |