Dynamo Kyiv 2-3 AFC Ajax *
| 25.08.2010 | AFC Ajax | 2-1 | Dynamo Kyiv | |
| 17.08.2010 | Dynamo Kyiv | 1-1 | AFC Ajax | |
Zenit 1-2 AJ Auxerre *
| 25.08.2010 | AJ Auxerre | 2-0 | Zenit | |
| 17.08.2010 | Zenit | 1-0 | AJ Auxerre | |
Rosenborg BK 2-2 FC København *
| 25.08.2010 | FC København | 1-0 | Rosenborg BK | |
| 17.08.2010 | Rosenborg BK | 2-1 | FC København | |
*FK Partizan 4-4 Anderlecht
| 24.08.2010 | Anderlecht | 2-2/p.2-3 | FK Partizan | |
| 18.08.2010 | FK Partizan | 2-2 | Anderlecht | |
RB Salzburg 3-4 Hapoel Tel Aviv *
| 24.08.2010 | Hapoel Tel Aviv | 1-1 | RB Salzburg | |
| 18.08.2010 | RB Salzburg | 2-3 | Hapoel Tel Aviv | |
*Werder Bremen 5-4 Sampdoria
| 24.08.2010 | Sampdoria | 3-2 AET | Werder Bremen | |
| 18.08.2010 | Werder Bremen | 3-1 | Sampdoria | |
*SC Braga 5-3 Sevilla FC
| 24.08.2010 | Sevilla FC | 3-4 | SC Braga | |
| 18.08.2010 | SC Braga | 1-0 | Sevilla FC | |
*FC Basel 4-0 Sheriff Tiraspol
| 24.08.2010 | Sheriff Tiraspol | 0-3 | FC Basel | |
| 18.08.2010 | FC Basel | 1-0 | Sheriff Tiraspol | |
Sparta Praha 0-3 MSK Zilina *
| 25.08.2010 | MSK Zilina | 1-0 | Sparta Praha | |
| 17.08.2010 | Sparta Praha | 0-2 | MSK Zilina | |
BSC Young Boys 3-6 Tottenham *
| 25.08.2010 | Tottenham | 4-0 | BSC Young Boys | |
| 17.08.2010 | BSC Young Boys | 3-2 | Tottenham | |