*AIK Fotboll 1-0 Jeunesse Esch
| 21.07.2010 | Jeunesse Esch | 0-0 | AIK Fotboll | |
| 13.07.2010 | AIK Fotboll | 1-0 | Jeunesse Esch | |
*BATE Borisov 6-1 FH Hafnarfjordur
| 21.07.2010 | FH Hafnarfjordur | 0-1 | BATE Borisov | |
| 14.07.2010 | BATE Borisov | 5-1 | FH Hafnarfjordur | |
*Sheriff Tiraspol 3-2 Dinamo Tirana
| 20.07.2010 | Dinamo Tirana | 1-0 | Sheriff Tiraspol | |
| 14.07.2010 | Sheriff Tiraspol | 3-1 | Dinamo Tirana | |
*FK Aktobe 3-1 Olimpi Rustavi
| 21.07.2010 | Olimpi Rustavi | 1-1 | FK Aktobe | |
| 14.07.2010 | FK Aktobe | 2-0 | Olimpi Rustavi | |
*Hapoel Tel Aviv 6-0 FK Zeljeznicar
| 21.07.2010 | FK Zeljeznicar | 0-1 | Hapoel Tel Aviv | |
| 13.07.2010 | Hapoel Tel Aviv | 5-0 | FK Zeljeznicar | |
FK Ekranas 1-2 HJK Helsinki *
| 21.07.2010 | HJK Helsinki | 2-0 AET | FK Ekranas | |
| 14.07.2010 | FK Ekranas | 1-0 | HJK Helsinki | |
*Dinamo Zagreb 5-4 Koper
| 20.07.2010 | Koper | 3-0 | Dinamo Zagreb | |
| 13.07.2010 | Dinamo Zagreb | 5-1 | Koper | |
Inter Baku 1-1 Lech Poznan *
| 21.07.2010 | Lech Poznan | 0-1/p.9-8 | Inter Baku | |
| 13.07.2010 | Inter Baku | 0-1 | Lech Poznan | |
Levadia Tallinn 3-4 Debrecen VSC *
| 21.07.2010 | Debrecen VSC | 3-2 | Levadia Tallinn | |
| 13.07.2010 | Levadia Tallinn | 1-1 | Debrecen VSC | |
Linfield Belfast 0-2 Rosenborg BK *
| 21.07.2010 | Rosenborg BK | 2-0 | Linfield Belfast | |
| 14.07.2010 | Linfield Belfast | 0-0 | Rosenborg BK | |
Litex Lovech 5-0 Rudar Pljevlja
| 20.07.2010 | Rudar Pljevlja | 0-4 | Litex Lovech | |
| 13.07.2010 | Litex Lovech | 1-0 | Rudar Pljevlja | |
Metalurgs Liepaja 0-5 Sparta Praha *
| 21.07.2010 | Sparta Praha | 2-0 | Metalurgs Liepaja | |
| 13.07.2010 | Metalurgs Liepaja | 0-3 | Sparta Praha | |
Birkirkara FC 1-3 MSK Zilina *
| 21.07.2010 | MSK Zilina | 3-0 | Birkirkara FC | |
| 13.07.2010 | Birkirkara FC | 1-0 | MSK Zilina | |
*FK Partizan 4-1 Pyunik FC
| 21.07.2010 | Pyunik FC | 0-1 | FK Partizan | |
| 14.07.2010 | FK Partizan | 3-1 | Pyunik FC | |
*RB Salzburg 5-1 HB Torshavn
| 20.07.2010 | HB Torshavn | 1-0 | RB Salzburg | |
| 13.07.2010 | RB Salzburg | 5-0 | HB Torshavn | |
*Omonia Nicosia 5-0 Renova
| 20.07.2010 | Renova | 0-2 | Omonia Nicosia | |
| 13.07.2010 | Omonia Nicosia | 3-0 | Renova | |
Bohemians FC 1-4 The New Saints *
| 20.07.2010 | The New Saints | 4-0 | Bohemians FC | |
| 13.07.2010 | Bohemians FC | 1-0 | The New Saints | |