*SL Benfica 3-2 AFC Ajax
| 15.03.2022 | AFC Ajax | 0-1 | SL Benfica | |
| 23.02.2022 | SL Benfica | 2-2 | AFC Ajax | |
RB Salzburg 2-8 Bayern München *
| 08.03.2022 | Bayern München | 7-1 | RB Salzburg | |
| 16.02.2022 | RB Salzburg | 1-1 | Bayern München | |
*Chelsea FC 4-1 Lille OSC
| 16.03.2022 | Lille OSC | 1-2 | Chelsea FC | |
| 22.02.2022 | Chelsea FC | 2-0 | Lille OSC | |
Inter Milan 1-2 Liverpool *
| 08.03.2022 | Liverpool | 0-1 | Inter Milan | |
| 16.02.2022 | Inter Milan | 0-2 | Liverpool | |
*Atlético Madrid 2-1 Manchester United
| 15.03.2022 | Manchester United | 0-1 | Atlético Madrid | |
| 23.02.2022 | Atlético Madrid | 1-1 | Manchester United | |
Paris St. Germain 2-3 Real Madrid *
| 09.03.2022 | Real Madrid | 3-1 | Paris St. Germain | |
| 15.02.2022 | Paris St. Germain | 1-0 | Real Madrid | |
Sporting Lisboa 0-5 Manchester City *
| 09.03.2022 | Manchester City | 0-0 | Sporting Lisboa | |
| 15.02.2022 | Sporting Lisboa | 0-5 | Manchester City | |
*Villarreal CF 4-1 Juventus FC
| 16.03.2022 | Juventus FC | 0-3 | Villarreal CF | |
| 22.02.2022 | Villarreal CF | 1-1 | Juventus FC | |