CFR Cluj 2-4 BSC Young Boys *
| 10.08.2021 | BSC Young Boys | 3-1 | CFR Cluj | |
| 03.08.2021 | CFR Cluj | 1-1 | BSC Young Boys | |
*Dinamo Zagreb 2-1 Legia Warszawa
| 10.08.2021 | Legia Warszawa | 0-1 | Dinamo Zagreb | |
| 04.08.2021 | Dinamo Zagreb | 1-1 | Legia Warszawa | |
Olympiakos Pireus 3-3 Ludogorets *
| 10.08.2021 | Ludogorets | 2-2/p.4-1 | Olympiakos Pireus | |
| 03.08.2021 | Olympiakos Pireus | 1-1 | Ludogorets | |
*Malmö FF 4-2 Rangers FC
| 10.08.2021 | Rangers FC | 1-2 | Malmö FF | |
| 03.08.2021 | Malmö FF | 2-1 | Rangers FC | |
FK Crvena Zvezda 1-2 Sheriff Tiraspol *
| 10.08.2021 | Sheriff Tiraspol | 1-0 | FK Crvena Zvezda | |
| 03.08.2021 | FK Crvena Zvezda | 1-1 | Sheriff Tiraspol | |
*Ferencvaros TC 2-1 Slavia Praha
| 10.08.2021 | Slavia Praha | 1-0 | Ferencvaros TC | |
| 04.08.2021 | Ferencvaros TC | 2-0 | Slavia Praha | |