Chelsea FC 4-5 Real Madrid *
| 12.04.2022 | Real Madrid | 2-3 AET | Chelsea FC | |
| 06.04.2022 | Chelsea FC | 1-3 | Real Madrid | |
*Manchester City 1-0 Atlético Madrid
| 13.04.2022 | Atlético Madrid | 0-0 | Manchester City | |
| 05.04.2022 | Manchester City | 1-0 | Atlético Madrid | |
SL Benfica 4-6 Liverpool *
| 13.04.2022 | Liverpool | 3-3 | SL Benfica | |
| 05.04.2022 | SL Benfica | 1-3 | Liverpool | |
*Villarreal CF 2-1 Bayern München
| 12.04.2022 | Bayern München | 1-1 | Villarreal CF | |
| 06.04.2022 | Villarreal CF | 1-0 | Bayern München | |