Ludogorets 3-6 Dinamo Zagreb *
| 09.08.2022 | Dinamo Zagreb | 4-2 | Ludogorets | |
| 02.08.2022 | Ludogorets | 1-2 | Dinamo Zagreb | |
*Qarabag FK 4-2 Ferencvaros TC
| 09.08.2022 | Ferencvaros TC | 1-3 | Qarabag FK | |
| 03.08.2022 | Qarabag FK | 1-1 | Ferencvaros TC | |
*FK Bodo/Glimt 6-1 VMFD Zalgiris
| 09.08.2022 | VMFD Zalgiris | 1-1 | FK Bodo/Glimt | |
| 03.08.2022 | FK Bodo/Glimt | 5-0 | VMFD Zalgiris | |
*Maccabi Haifa 4-2 Apollon Limassol
| 09.08.2022 | Apollon Limassol | 2-0 | Maccabi Haifa | |
| 03.08.2022 | Maccabi Haifa | 4-0 | Apollon Limassol | |
*FK Crvena Zvezda 7-0 Pyunik FC
| 09.08.2022 | Pyunik FC | 0-2 | FK Crvena Zvezda | |
| 03.08.2022 | FK Crvena Zvezda | 5-0 | Pyunik FC | |
Sheriff Tiraspol 2-4 Viktoria Plzen *
| 09.08.2022 | Viktoria Plzen | 2-1 | Sheriff Tiraspol | |
| 02.08.2022 | Sheriff Tiraspol | 1-2 | Viktoria Plzen | |