Celtic FC 1-5 FK Bodo/Glimt *
| 24.02.2022 | FK Bodo/Glimt | 2-0 | Celtic FC | |
| 17.02.2022 | Celtic FC | 1-3 | FK Bodo/Glimt | |
Sparta Praha 1-3 FK Partizan *
| 24.02.2022 | FK Partizan | 2-1 | Sparta Praha | |
| 17.02.2022 | Sparta Praha | 0-1 | FK Partizan | |
*Leicester City 7-2 Randers FC
| 24.02.2022 | Randers FC | 1-3 | Leicester City | |
| 17.02.2022 | Leicester City | 4-1 | Randers FC | |
*Olympique Marseille 6-1 Qarabag FK
| 24.02.2022 | Qarabag FK | 0-3 | Olympique Marseille | |
| 17.02.2022 | Olympique Marseille | 3-1 | Qarabag FK | |
FC Midtjylland 2-2 PAOK Salonica *
| 24.02.2022 | PAOK Salonica | 2-1/p.5-3 | FC Midtjylland | |
| 17.02.2022 | FC Midtjylland | 1-0 | PAOK Salonica | |
*PSV Eindhoven 2-1 Maccabi Tel Aviv
| 24.02.2022 | Maccabi Tel Aviv | 1-1 | PSV Eindhoven | |
| 17.02.2022 | PSV Eindhoven | 1-0 | Maccabi Tel Aviv | |
Rapid Wien 2-3 Vitesse Arnhem *
| 24.02.2022 | Vitesse Arnhem | 2-0 | Rapid Wien | |
| 17.02.2022 | Rapid Wien | 2-1 | Vitesse Arnhem | |
Fenerbahçe SK 4-6 Slavia Praha *
| 24.02.2022 | Slavia Praha | 3-2 | Fenerbahçe SK | |
| 17.02.2022 | Fenerbahçe SK | 2-3 | Slavia Praha | |