VMFD Zalgiris 2-3 FK Bodo/Glimt *
| 26.08.2021 | FK Bodo/Glimt | 1-0 | VMFD Zalgiris | |
| 19.08.2021 | VMFD Zalgiris | 2-2 | FK Bodo/Glimt | |
CS Fola Esch 2-7 Kairat Almaty *
| 26.08.2021 | Kairat Almaty | 3-1 | CS Fola Esch | |
| 19.08.2021 | CS Fola Esch | 1-4 | Kairat Almaty | |
Riga FC 2-4 Lincoln Red Imps *
| 26.08.2021 | Lincoln Red Imps | 3-1 AET | Riga FC | |
| 19.08.2021 | Riga FC | 1-1 | Lincoln Red Imps | |
Neftchi Baku 3-7 Maccabi Haifa *
| 26.08.2021 | Maccabi Haifa | 4-0 | Neftchi Baku | |
| 19.08.2021 | Neftchi Baku | 3-3 | Maccabi Haifa | |
*Flora Tallinn 5-2 Shamrock Rovers
| 26.08.2021 | Shamrock Rovers | 0-1 | Flora Tallinn | |
| 19.08.2021 | Flora Tallinn | 4-2 | Shamrock Rovers | |