Dinamo Tbilisi 2-7 Maccabi Haifa *
| 29.07.2021 | Maccabi Haifa | 5-1 | Dinamo Tbilisi | |
| 22.07.2021 | Dinamo Tbilisi | 1-2 | Maccabi Haifa | |
*HB Torshavn 6-0 FK Buducnost
| 27.07.2021 | FK Buducnost | 0-2 | HB Torshavn | |
| 22.07.2021 | HB Torshavn | 4-0 | FK Buducnost | |
Folgore Calcio 3-7 Hibernians Paola *
| 27.07.2021 | Hibernians Paola | 4-2 | Folgore Calcio | |
| 20.07.2021 | Folgore Calcio | 1-3 | Hibernians Paola | |
*KF Prishtina 6-5 Connah's Quay
| 29.07.2021 | Connah's Quay | 4-2 | KF Prishtina | |
| 20.07.2021 | KF Prishtina | 4-1 | Connah's Quay | |
*KF Teuta Durres 3-2 Inter d'Escaldes
| 27.07.2021 | Inter d'Escaldes | 0-3 AET | KF Teuta Durres | |
| 22.07.2021 | KF Teuta Durres | 0-2 | Inter d'Escaldes | |
*Linfield Belfast 4-0 Borac Banja Luka
| 29.07.2021 | Borac Banja Luka | 0-0 | Linfield Belfast | |
| 22.07.2021 | Linfield Belfast | 4-0 | Borac Banja Luka | |
Shakhter Soligorsk 1-3 CS Fola Esch *
| 29.07.2021 | CS Fola Esch | 1-0 | Shakhter Soligorsk | |
| 22.07.2021 | Shakhter Soligorsk | 1-2 | CS Fola Esch | |
*Riga FC 3-0 Shkendija'79
| 29.07.2021 | Shkendija'79 | 0-1 | Riga FC | |
| 22.07.2021 | Riga FC | 2-0 | Shkendija'79 | |
Valur Reykjavik 0-6 FK Bodo/Glimt *
| 29.07.2021 | FK Bodo/Glimt | 3-0 | Valur Reykjavik | |
| 22.07.2021 | Valur Reykjavik | 0-3 | FK Bodo/Glimt | |