*AEL Limassol 2-0 Vllaznia Shkodër
| 29.07.2021 | Vllaznia Shkodër | 0-1 | AEL Limassol | |
| 22.07.2021 | AEL Limassol | 1-0 | Vllaznia Shkodër | |
*Larne FC 3-2 AGF Aarhus
| 29.07.2021 | AGF Aarhus | 1-1 | Larne FC | |
| 22.07.2021 | Larne FC | 2-1 | AGF Aarhus | |
Ararat Yerevan 5-7 Śląsk Wrocław *
| 29.07.2021 | Śląsk Wrocław | 3-3 | Ararat Yerevan | |
| 22.07.2021 | Ararat Yerevan | 2-4 | Śląsk Wrocław | |
Arda Kardzhali 0-6 Hapoel Be'er Sheva *
| 29.07.2021 | Hapoel Be'er Sheva | 4-0 | Arda Kardzhali | |
| 22.07.2021 | Arda Kardzhali | 0-2 | Hapoel Be'er Sheva | |
*Dinamo Batumi 4-2 BATE Borisov
| 29.07.2021 | BATE Borisov | 1-4 | Dinamo Batumi | |
| 22.07.2021 | Dinamo Batumi | 0-1 | BATE Borisov | |
*Olimpija Ljubljana 1-1 Birkirkara FC
| 29.07.2021 | Birkirkara FC | 1-0/p.4-5 | Olimpija Ljubljana | |
| 22.07.2021 | Olimpija Ljubljana | 1-0 | Birkirkara FC | |
*Aberdeen FC 5-3 BK Häcken
| 29.07.2021 | BK Häcken | 2-0 | Aberdeen FC | |
| 22.07.2021 | Aberdeen FC | 5-1 | BK Häcken | |
Austria Wien 2-3 Breidablik *
| 29.07.2021 | Breidablik | 2-1 | Austria Wien | |
| 22.07.2021 | Austria Wien | 1-1 | Breidablik | |
*Cukaricki Belgrade 2-0 Sumqayit FK
| 29.07.2021 | Sumqayit FK | 0-2 | Cukaricki Belgrade | |
| 21.07.2021 | Cukaricki Belgrade | 0-0 | Sumqayit FK | |
*Viktoria Plzen 4-2 Dinamo Brest
| 29.07.2021 | Dinamo Brest | 1-2 | Viktoria Plzen | |
| 22.07.2021 | Viktoria Plzen | 2-1 | Dinamo Brest | |
*FK Partizan 3-0 Dunajska Streda
| 29.07.2021 | Dunajska Streda | 0-2 | FK Partizan | |
| 22.07.2021 | FK Partizan | 1-0 | Dunajska Streda | |
*Dundalk FC 4-3 Levadia Tallinn
| 29.07.2021 | Levadia Tallinn | 1-2 | Dundalk FC | |
| 22.07.2021 | Dundalk FC | 2-2 | Levadia Tallinn | |
F91 Dudelange 0-4 Bohemians FC *
| 29.07.2021 | Bohemians FC | 3-0 | F91 Dudelange | |
| 22.07.2021 | F91 Dudelange | 0-1 | Bohemians FC | |
*FC Astana 3-2 Aris Salonica
| 29.07.2021 | Aris Salonica | 2-1 AET | FC Astana | |
| 22.07.2021 | FC Astana | 2-0 | Aris Salonica | |
*FC Basel 5-0 Partizani Tirana
| 29.07.2021 | Partizani Tirana | 0-2 | FC Basel | |
| 22.07.2021 | FC Basel | 3-0 | Partizani Tirana | |
*Domžale 2-1 FC Honka Espoo
| 29.07.2021 | FC Honka Espoo | 0-1 | Domžale | |
| 20.07.2021 | Domžale | 1-1 | FC Honka Espoo | |
FCSB 2-2 Shakhtyor Karagandy *
| 29.07.2021 | Shakhtyor Karagandy | 2-1/p.5-3 | FCSB | |
| 22.07.2021 | FCSB | 1-0 | Shakhtyor Karagandy | |
FH Hafnarfjordur 1-6 Rosenborg BK *
| 29.07.2021 | Rosenborg BK | 4-1 | FH Hafnarfjordur | |
| 22.07.2021 | FH Hafnarfjordur | 0-2 | Rosenborg BK | |
*CSKA Sofia 0-0 FK Liepaja
| 29.07.2021 | FK Liepaja | 0-0/p.1-3 | CSKA Sofia | |
| 22.07.2021 | CSKA Sofia | 0-0 | FK Liepaja | |
*FK RFS 5-0 Puskás Akadémia
| 29.07.2021 | Puskás Akadémia | 0-2 | FK RFS | |
| 22.07.2021 | FK RFS | 3-0 | Puskás Akadémia | |
FK Panevezys 0-2 FK Vojvodina *
| 29.07.2021 | FK Vojvodina | 1-0 | FK Panevezys | |
| 22.07.2021 | FK Panevezys | 0-1 | FK Vojvodina | |
Hajduk Split 3-4 Tobol Kostanay *
| 29.07.2021 | Tobol Kostanay | 4-1 AET | Hajduk Split | |
| 22.07.2021 | Hajduk Split | 2-0 | Tobol Kostanay | |
*Hibernian FC 5-1 FC Santa Coloma
| 29.07.2021 | FC Santa Coloma | 1-2 | Hibernian FC | |
| 22.07.2021 | Hibernian FC | 3-0 | FC Santa Coloma | |
Gzira United 0-3 HNK Rijeka *
| 29.07.2021 | HNK Rijeka | 1-0 | Gzira United | |
| 22.07.2021 | Gzira United | 0-2 | HNK Rijeka | |
*IF Elfsborg 9-0 FC Milsami
| 29.07.2021 | FC Milsami | 0-5 | IF Elfsborg | |
| 22.07.2021 | IF Elfsborg | 4-0 | FC Milsami | |
*KF Laci 1-0 Universitatea Craiova
| 29.07.2021 | Universitatea Craiova | 0-0 | KF Laci | |
| 22.07.2021 | KF Laci | 1-0 | Universitatea Craiova | |
Sutjeska Niksic 1-3 Maccabi Tel Aviv *
| 29.07.2021 | Maccabi Tel Aviv | 3-1 | Sutjeska Niksic | |
| 22.07.2021 | Sutjeska Niksic | 0-0 | Maccabi Tel Aviv | |
*Hammarby IF 4-1 Maribor
| 29.07.2021 | Maribor | 0-1 | Hammarby IF | |
| 22.07.2021 | Hammarby IF | 3-1 | Maribor | |
*Molde FK 3-2 Servette FC
| 29.07.2021 | Servette FC | 2-0 | Molde FK | |
| 22.07.2021 | Molde FK | 3-0 | Servette FC | |
Apollon Limassol 3-5 MSK Zilina *
| 29.07.2021 | MSK Zilina | 2-2 | Apollon Limassol | |
| 22.07.2021 | Apollon Limassol | 1-3 | MSK Zilina | |
Pogoń Szczecin 0-1 NK Osijek *
| 29.07.2021 | NK Osijek | 1-0 | Pogoń Szczecin | |
| 22.07.2021 | Pogoń Szczecin | 0-0 | NK Osijek | |
*Qarabag FK 1-0 FC Ashdod
| 29.07.2021 | FC Ashdod | 0-1 | Qarabag FK | |
| 22.07.2021 | Qarabag FK | 0-0 | FC Ashdod | |
*Spartak Trnava 1-1 Sepsi OSK
| 29.07.2021 | Sepsi OSK | 1-1/p.3-4 | Spartak Trnava | |
| 22.07.2021 | Spartak Trnava | 0-0 | Sepsi OSK | |
Shkupi 0-5 CD Santa Clara *
| 29.07.2021 | CD Santa Clara | 2-0 | Shkupi | |
| 22.07.2021 | Shkupi | 0-3 | CD Santa Clara | |
Petrocub Hîncești 0-2 Sivasspor *
| 29.07.2021 | Sivasspor | 1-0 | Petrocub Hîncești | |
| 22.07.2021 | Petrocub Hîncești | 0-1 | Sivasspor | |
*Lokomotiv Plovdiv 1-1 Slovacko
| 29.07.2021 | Slovacko | 1-0/p.2-3 | Lokomotiv Plovdiv | |
| 22.07.2021 | Lokomotiv Plovdiv | 1-0 | Slovacko | |
FK Kauno Zalgiris 1-10 The New Saints *
| 29.07.2021 | The New Saints | 5-1 | FK Kauno Zalgiris | |
| 20.07.2021 | FK Kauno Zalgiris | 0-5 | The New Saints | |
*FC København 9-1 Torpedo Zhodino
| 29.07.2021 | Torpedo Zhodino | 0-5 | FC København | |
| 22.07.2021 | FC København | 4-1 | Torpedo Zhodino | |
*Velez Mostar 2-2 AEK Athens
| 29.07.2021 | AEK Athens | 1-0/p.2-3 | Velez Mostar | |
| 22.07.2021 | Velez Mostar | 2-1 | AEK Athens | |
*KuPS Kuopio 5-4 Vorskla
| 29.07.2021 | Vorskla | 2-3 AET | KuPS Kuopio | |
| 22.07.2021 | KuPS Kuopio | 2-2 | Vorskla | |