*Feyenoord 6-4 Slavia Praha
| 14.04.2022 | Slavia Praha | 1-3 | Feyenoord | |
| 07.04.2022 | Feyenoord | 3-3 | Slavia Praha | |
FK Bodo/Glimt 2-5 AS Roma *
| 14.04.2022 | AS Roma | 4-0 | FK Bodo/Glimt | |
| 07.04.2022 | FK Bodo/Glimt | 2-1 | AS Roma | |
*Leicester City 2-1 PSV Eindhoven
| 14.04.2022 | PSV Eindhoven | 1-2 | Leicester City | |
| 07.04.2022 | Leicester City | 0-0 | PSV Eindhoven | |
*Olympique Marseille 3-1 PAOK Salonica
| 14.04.2022 | PAOK Salonica | 0-1 | Olympique Marseille | |
| 07.04.2022 | Olympique Marseille | 2-1 | PAOK Salonica | |