*AEK Larnaca 1-0 SK Dnipro-1
| 23.02.2023 | SK Dnipro-1 | 0-0 | AEK Larnaca | |
| 16.02.2023 | AEK Larnaca | 1-0 | SK Dnipro-1 | |
Ludogorets 2-2 Anderlecht *
| 23.02.2023 | Anderlecht | 2-1/p.3-0 | Ludogorets | |
| 16.02.2023 | Ludogorets | 1-0 | Anderlecht | |
SC Braga 2-7 Fiorentina *
| 23.02.2023 | Fiorentina | 3-2 | SC Braga | |
| 16.02.2023 | SC Braga | 0-4 | Fiorentina | |
*Sheriff Tiraspol 3-2 FK Partizan
| 23.02.2023 | FK Partizan | 1-3 | Sheriff Tiraspol | |
| 16.02.2023 | Sheriff Tiraspol | 0-1 | FK Partizan | |
Qarabag FK 1-1 KAA Gent *
| 23.02.2023 | KAA Gent | 1-0/p.5-3 | Qarabag FK | |
| 16.02.2023 | Qarabag FK | 1-0 | KAA Gent | |
FK Bodo/Glimt 0-1 Lech Poznan *
| 23.02.2023 | Lech Poznan | 1-0 | FK Bodo/Glimt | |
| 16.02.2023 | FK Bodo/Glimt | 0-0 | Lech Poznan | |
Trabzonspor 1-2 FC Basel *
| 23.02.2023 | FC Basel | 2-0 | Trabzonspor | |
| 16.02.2023 | Trabzonspor | 1-0 | FC Basel | |