*Djurgårdens IF 5-3 APOEL FC
| 23.08.2022 | APOEL FC | 3-2 | Djurgårdens IF | |
| 17.08.2022 | Djurgårdens IF | 3-0 | APOEL FC | |
*AZ Alkmaar 6-1 Gil Vicente
| 25.08.2022 | Gil Vicente | 1-2 | AZ Alkmaar | |
| 18.08.2022 | AZ Alkmaar | 4-0 | Gil Vicente | |
BSC Young Boys 1-1 Anderlecht *
| 25.08.2022 | Anderlecht | 0-1/p.3-1 | BSC Young Boys | |
| 18.08.2022 | BSC Young Boys | 0-1 | Anderlecht | |
CSKA Sofia 1-2 FC Basel *
| 25.08.2022 | FC Basel | 2-0 | CSKA Sofia | |
| 18.08.2022 | CSKA Sofia | 1-0 | FC Basel | |
*Fiorentina 2-1 FC Twente
| 25.08.2022 | FC Twente | 0-0 | Fiorentina | |
| 18.08.2022 | Fiorentina | 2-1 | FC Twente | |
1.FC Köln 4-2 Fehervar FC
| 25.08.2022 | Fehervar FC | 0-3 | 1.FC Köln | |
| 18.08.2022 | 1.FC Köln | 1-2 | Fehervar FC | |
*FK Partizan 7-4 Hamrun Spartans
| 25.08.2022 | Hamrun Spartans | 3-3 | FK Partizan | |
| 18.08.2022 | FK Partizan | 4-1 | Hamrun Spartans | |
Universitatea Craiova 2-2 Hapoel Be'er Sheva *
| 25.08.2022 | Hapoel Be'er Sheva | 1-1/p.4-3 | Universitatea Craiova | |
| 18.08.2022 | Universitatea Craiova | 1-1 | Hapoel Be'er Sheva | |
*Istanbul Basaksehir 4-2 Royal Antwerp
| 25.08.2022 | Royal Antwerp | 1-3 | Istanbul Basaksehir | |
| 18.08.2022 | Istanbul Basaksehir | 1-1 | Royal Antwerp | |
Maccabi Tel Aviv 1-2 OGC Nice *
| 25.08.2022 | OGC Nice | 2-0 AET | Maccabi Tel Aviv | |
| 18.08.2022 | Maccabi Tel Aviv | 1-0 | OGC Nice | |
Raków 2-3 Slavia Praha *
| 25.08.2022 | Slavia Praha | 2-0 AET | Raków | |
| 18.08.2022 | Raków | 2-1 | Slavia Praha | |
*FC Vaduz 2-1 Rapid Wien
| 25.08.2022 | Rapid Wien | 0-1 | FC Vaduz | |
| 18.08.2022 | FC Vaduz | 1-1 | Rapid Wien | |
*Slovacko 4-0 AIK Fotboll
| 25.08.2022 | AIK Fotboll | 0-1 | Slovacko | |
| 18.08.2022 | Slovacko | 3-0 | AIK Fotboll | |
*Villarreal CF 6-2 Hajduk Split
| 25.08.2022 | Hajduk Split | 0-2 | Villarreal CF | |
| 18.08.2022 | Villarreal CF | 4-2 | Hajduk Split | |
*Molde FK 4-1 Wolfsberger AC
| 25.08.2022 | Wolfsberger AC | 0-4 | Molde FK | |
| 18.08.2022 | Molde FK | 0-1 | Wolfsberger AC | |