Botev Plovdiv 0-2 APOEL FC *
| 28.07.2022 | APOEL FC | 2-0 | Botev Plovdiv | |
| 20.07.2022 | Botev Plovdiv | 0-0 | APOEL FC | |
Aris Limassol 2-3 Neftchi Baku *
| 28.07.2022 | Neftchi Baku | 3-0 | Aris Limassol | |
| 21.07.2022 | Aris Limassol | 2-0 | Neftchi Baku | |
*Aris Salonica 7-2 FC Gomel
| 27.07.2022 | FC Gomel | 1-2 | Aris Salonica | |
| 21.07.2022 | Aris Salonica | 5-1 | FC Gomel | |
AZ Alkmaar 5-0 FK Tuzla City
| 28.07.2022 | FK Tuzla City | 0-4 | AZ Alkmaar | |
| 21.07.2022 | AZ Alkmaar | 1-0 | FK Tuzla City | |
*B36 Torshavn 1-0 SP Tre Fiori
| 28.07.2022 | SP Tre Fiori | 0-0 | B36 Torshavn | |
| 21.07.2022 | B36 Torshavn | 1-0 | SP Tre Fiori | |
BATE Borisov 0-5 Konyaspor *
| 28.07.2022 | Konyaspor | 2-0 | BATE Borisov | |
| 21.07.2022 | BATE Borisov | 0-3 | Konyaspor | |
*Breidablik 3-2 FK Buducnost
| 28.07.2022 | FK Buducnost | 2-1 | Breidablik | |
| 21.07.2022 | Breidablik | 2-0 | FK Buducnost | |
RFCU Luxemburg 1-8 Cukaricki Belgrade *
| 28.07.2022 | Cukaricki Belgrade | 4-0 | RFCU Luxemburg | |
| 21.07.2022 | RFCU Luxemburg | 1-4 | Cukaricki Belgrade | |
*Hapoel Be'er Sheva 3-1 Dinamo Minsk
| 28.07.2022 | Dinamo Minsk | 0-1 | Hapoel Be'er Sheva | |
| 21.07.2022 | Hapoel Be'er Sheva | 2-1 | Dinamo Minsk | |
HNK Rijeka 1-4 Djurgårdens IF *
| 28.07.2022 | Djurgårdens IF | 2-0 | HNK Rijeka | |
| 21.07.2022 | HNK Rijeka | 1-2 | Djurgårdens IF | |
Vikingur Gota 0-4 Dunajska Streda *
| 28.07.2022 | Dunajska Streda | 2-0 | Vikingur Gota | |
| 20.07.2022 | Vikingur Gota | 0-2 | Dunajska Streda | |
FC Ararat-Armenia 0-0 Paide Linnameeskond *
| 28.07.2022 | Paide Linnameeskond | 0-0/p.5-3 | FC Ararat-Armenia | |
| 21.07.2022 | FC Ararat-Armenia | 0-0 | Paide Linnameeskond | |
*FC Basel 3-1 Crusaders Belfast
| 28.07.2022 | Crusaders Belfast | 1-1 | FC Basel | |
| 21.07.2022 | FC Basel | 2-0 | Crusaders Belfast | |
FC Iberia 1999 3-4 FCSB *
| 28.07.2022 | FCSB | 4-2 | FC Iberia 1999 | |
| 21.07.2022 | FC Iberia 1999 | 1-0 | FCSB | |
*KuPS Kuopio 6-3 FC Milsami
| 28.07.2022 | FC Milsami | 1-4 | KuPS Kuopio | |
| 21.07.2022 | KuPS Kuopio | 2-2 | FC Milsami | |
FK Liepaja 0-4 BSC Young Boys *
| 28.07.2022 | BSC Young Boys | 3-0 | FK Liepaja | |
| 21.07.2022 | FK Liepaja | 0-1 | BSC Young Boys | |
*Fehervar FC 5-3 Gabala FC
| 28.07.2022 | Gabala FC | 2-1 | Fehervar FC | |
| 21.07.2022 | Fehervar FC | 4-1 | Gabala FC | |
*Molde FK 6-2 IF Elfsborg
| 28.07.2022 | IF Elfsborg | 1-2 | Molde FK | |
| 21.07.2022 | Molde FK | 4-1 | IF Elfsborg | |
Kairat Almaty 0-2 Kisvárda FC *
| 28.07.2022 | Kisvárda FC | 1-0 | Kairat Almaty | |
| 21.07.2022 | Kairat Almaty | 0-1 | Kisvárda FC | |
*Rapid Wien 2-1 Lechia Gdansk
| 28.07.2022 | Lechia Gdansk | 1-2 | Rapid Wien | |
| 21.07.2022 | Rapid Wien | 0-0 | Lechia Gdansk | |
*Levski Sofia 3-1 PAOK Salonica
| 28.07.2022 | PAOK Salonica | 1-1 | Levski Sofia | |
| 21.07.2022 | Levski Sofia | 2-0 | PAOK Salonica | |
Seinajoen JK 2-6 Lillestrom SK *
| 28.07.2022 | Lillestrom SK | 5-2 | Seinajoen JK | |
| 21.07.2022 | Seinajoen JK | 0-1 | Lillestrom SK | |
*Istanbul Basaksehir 2-1 Maccabi Netanya
| 28.07.2022 | Maccabi Netanya | 0-1 | Istanbul Basaksehir | |
| 21.07.2022 | Istanbul Basaksehir | 1-1 | Maccabi Netanya | |
Zira FK 0-3 Maccabi Tel Aviv *
| 28.07.2022 | Maccabi Tel Aviv | 0-0 | Zira FK | |
| 21.07.2022 | Zira FK | 0-3 | Maccabi Tel Aviv | |
Makedonija GP 0-4 CSKA Sofia *
| 28.07.2022 | CSKA Sofia | 4-0 | Makedonija GP | |
| 21.07.2022 | Makedonija GP | 0-0 | CSKA Sofia | |
Motherwell FC 0-3 Sligo Rovers *
| 28.07.2022 | Sligo Rovers | 2-0 | Motherwell FC | |
| 21.07.2022 | Motherwell FC | 0-1 | Sligo Rovers | |
*St Patrick's Dublin 1-1 Mura
| 28.07.2022 | Mura | 0-0/p.5-6 | St Patrick's Dublin | |
| 21.07.2022 | St Patrick's Dublin | 1-1 | Mura | |
*FK Kyzylzhar 3-2 NK Osijek
| 28.07.2022 | NK Osijek | 0-2 | FK Kyzylzhar | |
| 21.07.2022 | FK Kyzylzhar | 1-2 | NK Osijek | |
*Petrocub Hîncești 4-1 KF Laci
| 28.07.2022 | KF Laci | 1-4 | Petrocub Hîncești | |
| 21.07.2022 | Petrocub Hîncești | 0-0 | KF Laci | |
Pogoń Szczecin 1-5 Brøndby IF *
| 28.07.2022 | Brøndby IF | 4-0 | Pogoń Szczecin | |
| 21.07.2022 | Pogoń Szczecin | 1-1 | Brøndby IF | |
*Vitória Guimarães 3-0 Puskás Akadémia
| 28.07.2022 | Puskás Akadémia | 0-0 | Vitória Guimarães | |
| 21.07.2022 | Vitória Guimarães | 3-0 | Puskás Akadémia | |
*Gzira United 5-5 Radnicki Nis
| 28.07.2022 | Radnicki Nis | 3-3/p.1-3 | Gzira United | |
| 21.07.2022 | Gzira United | 2-2 | Radnicki Nis | |
MFK Ruzomberok 1-5 Riga FC *
| 28.07.2022 | Riga FC | 2-1 | MFK Ruzomberok | |
| 21.07.2022 | MFK Ruzomberok | 0-3 | Riga FC | |
*Royal Antwerp 2-0 Drita FC
| 28.07.2022 | Drita FC | 0-2 | Royal Antwerp | |
| 21.07.2022 | Royal Antwerp | 0-0 | Drita FC | |
*Sepsi OSK 3-3 Olimpija Ljubljana
| 28.07.2022 | Olimpija Ljubljana | 2-0/p.2-4 | Sepsi OSK | |
| 21.07.2022 | Sepsi OSK | 3-1 | Olimpija Ljubljana | |
Valmieras FK 2-5 Shkendija'79 *
| 28.07.2022 | Shkendija'79 | 3-1 | Valmieras FK | |
| 21.07.2022 | Valmieras FK | 1-2 | Shkendija'79 | |
Sparta Praha 1-2 Viking FK *
| 28.07.2022 | Viking FK | 2-1 | Sparta Praha | |
| 21.07.2022 | Sparta Praha | 0-0 | Viking FK | |
*Spartak Trnava 6-2 Newtown AFC
| 28.07.2022 | Newtown AFC | 1-2 | Spartak Trnava | |
| 21.07.2022 | Spartak Trnava | 4-1 | Newtown AFC | |
St Joseph's (GIB) 0-11 Slavia Praha *
| 28.07.2022 | Slavia Praha | 7-0 | St Joseph's (GIB) | |
| 21.07.2022 | St Joseph's (GIB) | 0-4 | Slavia Praha | |
Velez Mostar 0-2 Hamrun Spartans *
| 28.07.2022 | Hamrun Spartans | 1-0 | Velez Mostar | |
| 21.07.2022 | Velez Mostar | 0-1 | Hamrun Spartans | |
Vllaznia Shkodër 1-4 Universitatea Craiova *
| 28.07.2022 | Universitatea Craiova | 3-0 | Vllaznia Shkodër | |
| 21.07.2022 | Vllaznia Shkodër | 1-1 | Universitatea Craiova | |
Vorskla 3-4 AIK Fotboll *
| 27.07.2022 | AIK Fotboll | 2-0 AET | Vorskla | |
| 21.07.2022 | Vorskla | 3-2 | AIK Fotboll | |